 | 1 | XBiotech Inc. |  | 448.32% | 0.0 |  |
 | 2 | ARENA PHARMACEUTICALS INC | | 383.96% | 11.0 |  |
| 3 | BIOSPECIFICS TECHNOLOGIES CORP | | 374.57% | 1.0 |  |
 | 4 | CNBX Pharmaceuticals Inc. | | 357.16% | 221.0 | |
 | 5 | Catalent Inc. | | 330.59% | 23.0 | |
 | 6 | MARIZYME INC. | | 330.24% | 1.0 | |
 | 7 | ENANTA PHARMACEUTICALS INC | | 325.68% | -1.0 |  |
 | 8 | CORCEPT THERAPEUTICS INC | | 323.21% | 3.0 | |
 | 9 | Jazz Pharmaceuticals plc | | 318.82% | 3.0 | |
 | 10 | Karuna Therapeutics Inc. | | 316.41% | 0.0 | |
| 11 | Viking Therapeutics Inc. | | 309.61% | -2.0 | |
 | 12 | OPIANT PHARMACEUTICALS INC. | | 306.81% | 216.0 | |
| 13 | Stoke Therapeutics Inc. | | 303.50% | 0.0 | |
| 14 | RENOVARO BIOSCIENCES INC. | | 299.71% | 23.0 | |
| 15 | AKCEA THERAPEUTICS INC. | | 297.46% | 153.0 | |
 | 16 | Vanda Pharmaceuticals Inc. | | 295.57% | 20.0 | |
| 17 | Principia Biopharma Inc. | | 287.98% | 3.0 | |
 | 18 | Xencor Inc | | 280.54% | 15.0 | |
 | 19 | MEDICINOVA INC | | 277.50% | 3.0 | |
| 20 | Chemomab Therapeutics Ltd. | | 277.19% | 0.0 | |
 | 21 | MADRIGAL PHARMACEUTICALS INC. | | 270.69% | -11.0 |  |
 | 22 | CASSAVA SCIENCES INC | | 268.40% | 10.0 | |
 | 23 | CATALYST PHARMACEUTICALS INC. | | 266.35% | 101.0 | |
 | 24 | NextCure Inc. | | 265.67% | 0.0 | |
 | 25 | ANAPTYSBIO INC | | 258.51% | -11.0 | |
| 26 | Aprea Therapeutics Inc. | | 257.75% | 0.0 | |
 | 27 | ABBOTT LABORATORIES | | 257.34% | 4.0 | |
| 28 | Pfenex Inc. | | 257.32% | 118.0 | |
 | 29 | AbbVie Inc. | | 255.58% | 46.0 | |
 | 30 | PROCYON CORP | | 253.92% | 13.0 | |
 | 31 | GALECTIN THERAPEUTICS INC | | 253.72% | 248.0 | |
 | 32 | Monopar Therapeutics | | 248.52% | 25.0 | |
 | 33 | Atreca Inc. | | 248.51% | 0.0 | |
 | 34 | China Health Industries Holdings Inc. | | 245.09% | 0.0 | |
 | 35 | NGM BIOPHARMACEUTICALS INC | | 244.69% | 0.0 | |
 | 36 | Endo International plc | | 243.70% | 27.0 | |
| 37 | GW PHARMACEUTICALS PLC | | 239.74% | 89.0 | |
| 38 | Kura Oncology Inc. | | 236.38% | 29.0 | |
 | 39 | TFF Pharmaceuticals Inc. | | 232.21% | 0.0 | |
 | 40 | REGENERON PHARMACEUTICALS INC. | | 229.01% | 6.0 | |
 | 41 | BIO-PATH HOLDINGS INC | | 228.35% | 305.0 | |
 | 42 | GLYCOMIMETICS INC | | 228.17% | -19.0 | |
| 43 | Ra Pharmaceuticals Inc. | | 227.41% | -4.0 | |
 | 44 | AGILE THERAPEUTICS INC | | 225.28% | 109.0 | |
 | 45 | Y-mAbs Therapeutics Inc. | | 223.33% | -3.0 | |
 | 46 | ACADIA PHARMACEUTICALS INC | | 223.14% | 38.0 | |
 | 47 | VERTEX PHARMACEUTICALS INC MA | | 220.67% | 38.0 | |
 | 48 | Merck & Co. Inc. | | 218.41% | 21.0 | |
 | 49 | Epizyme Inc. | | 218.27% | 46.0 | |
| 50 | Provention Bio Inc. | | 218.23% | -6.0 | |
 | 51 | Deciphera Pharmaceuticals Inc. | | 214.14% | 0.0 | |
 | 52 | ARROWHEAD PHARMACEUTICALS INC. | | 213.99% | 51.0 | |
 | 53 | Aravive Inc. | | 211.25% | 152.0 | |
 | 54 | Mirum Pharmaceuticals Inc. | | 210.59% | 0.0 | |
 | 55 | Amphastar Pharmaceuticals Inc. | | 209.73% | 35.0 | |
 | 56 | Aptinyx Inc. | | 209.31% | -16.0 | |
 | 57 | KalVista Pharmaceuticals Inc. | | 208.08% | 149.0 | |
 | 58 | ROCKET PHARMACEUTICALS INC. | | 206.60% | 50.0 | |
 | 59 | BICYCLE THERAPEUTICS plc | | 204.11% | 0.0 | |
 | 60 | PREDICTIVE TECHNOLOGY GROUP INC. | | 204.03% | 0.0 | |
 | 61 | RHYTHM PHARMACEUTICALS INC. | | 203.93% | 0.0 | |
 | 62 | G1 Therapeutics Inc. | | 201.86% | -41.0 | |
 | 63 | Ayala Pharmaceuticals Inc. | | 201.56% | 220.0 | |
 | 64 | IVERIC bio Inc. | | 199.38% | -61.0 | |
 | 65 | Histogen Inc. | | 198.96% | 118.0 | |
 | 66 | SYNLOGIC INC. | | 198.50% | 2.0 | |
 | 67 | EAGLE PHARMACEUTICALS INC. | | 195.49% | -38.0 | |
 | 68 | CymaBay Therapeutics Inc. | | 193.49% | -7.0 | |
 | 69 | Korro Bio Inc. | | 192.88% | 0.0 | |
| 70 | ARTELO BIOSCIENCES INC. | | 192.49% | 289.0 | |
 | 71 | Zynerba Pharmaceuticals Inc. | | 191.54% | 52.0 | |
 | 72 | RELIV INTERNATIONAL INC | | 191.40% | 24.0 | |
 | 73 | Homology Medicines Inc. | | 187.99% | 28.0 | |
 | 74 | UNITED THERAPEUTICS Corp | | 185.27% | -50.0 | |
 | 75 | Altimmune Inc. | | 184.63% | 57.0 | |
 | 76 | Mirati Therapeutics Inc. | | 184.40% | 7.0 | |
 | 77 | ASSEMBLY BIOSCIENCES INC. | | 183.17% | 32.0 | |
| 78 | ALEXION PHARMACEUTICALS INC. | | 182.75% | 28.0 | |
 | 79 | UroGen Pharma Ltd. | | 182.75% | 60.0 | |
 | 80 | Dianthus Therapeutics Inc. DE | | 182.68% | 0.0 | |
 | 81 | Aadi Bioscience Inc. | | 182.61% | -47.0 | |
| 82 | Axsome Therapeutics Inc. | | 182.22% | 239.0 | |
 | 83 | Avid Bioservices Inc. | | 178.79% | 77.0 | |
 | 84 | ALIMERA SCIENCES INC | | 177.45% | 9.0 | |
 | 85 | AMARIN CORP PLC\UK | | 177.06% | 136.0 | |
 | 86 | LIGAND PHARMACEUTICALS INC | | 175.41% | 78.0 | |
 | 87 | GERON CORP | | 173.34% | -72.0 | |
 | 88 | ABEONA THERAPEUTICS INC. | | 171.89% | -61.0 | |
 | 89 | Hepion Pharmaceuticals Inc. | | 171.16% | 211.0 | |
 | 90 | BIOMARIN PHARMACEUTICAL INC | | 171.12% | 12.0 | |
 | 91 | ARVINAS INC. | | 169.82% | 36.0 | |
| 92 | Kadmon Holdings Inc. | | 169.56% | 93.0 | |
| 93 | FIVE PRIME THERAPEUTICS INC. | | 168.97% | -23.0 | |
| 94 | MyoKardia Inc. | | 167.18% | -59.0 | |
 | 95 | Matinas BioPharma Holdings Inc. | | 166.46% | 67.0 | |
 | 96 | OPKO HEALTH INC. | | 163.89% | -8.0 | |
 | 97 | Arcus Biosciences Inc. | | 162.71% | -42.0 | |
 | 98 | Cyclerion Therapeutics Inc. | | 162.50% | 0.0 | |
 | 99 | Syros Pharmaceuticals Inc. | | 162.47% | 38.0 | |
| 100 | Neurotrope Inc. | | 161.35% | -35.0 | |
 | 101 | Kiniksa Pharmaceuticals Ltd. | | 159.27% | -29.0 | |
 | 102 | Calithera Biosciences Inc. | | 159.08% | -28.0 | |
 | 103 | HERON THERAPEUTICS INC. DE | | 157.60% | 7.0 | |
| 104 | Corvus Pharmaceuticals Inc. | | 157.35% | -51.0 | |
 | 105 | Mersana Therapeutics Inc. | | 155.77% | 187.0 | |
 | 106 | NEKTAR THERAPEUTICS | | 155.28% | -87.0 | |
 | 107 | Elanco Animal Health Inc | | 155.06% | 26.0 | |
 | 108 | NATURES SUNSHINE PRODUCTS INC | | 154.70% | 12.0 | |
 | 109 | Sage Therapeutics Inc. | | 154.53% | -43.0 | |
 | 110 | Guardion Health Sciences Inc. | | 154.20% | 195.0 | |
 | 111 | uniQure N.V. | | 150.38% | 43.0 | |
 | 112 | EXICURE INC. | | 150.33% | 90.0 | |
 | 113 | Oncotelic Therapeutics Inc. | | 147.26% | 230.0 | |
 | 114 | Astria Therapeutics Inc. | | 146.93% | 5.0 | |
| 115 | TENAX THERAPEUTICS INC. | | 144.87% | -90.0 | |
| 116 | Allergan plc | | 144.45% | 6.0 | |
 | 117 | Global Blood Therapeutics Inc. | | 143.86% | 0.0 | |
 | 118 | PROTHENA CORP PUBLIC LTD CO | | 138.52% | 38.0 | |
 | 119 | BridgeBio Pharma Inc. | | 138.24% | 0.0 | |
 | 120 | Unity Biotechnology Inc. | | 138.15% | -41.0 | |
 | 121 | ARDELYX INC. | | 135.85% | 72.0 | |
| 122 | Equillium Inc. | | 134.01% | -106.0 | |
 | 123 | IONIS PHARMACEUTICALS INC | | 133.82% | 46.0 | |
 | 124 | SUPERNUS PHARMACEUTICALS INC. | | 132.45% | 33.0 | |
 | 125 | Salarius Pharmaceuticals Inc. | | 130.90% | 178.0 | |
 | 126 | Lifevantage Corp | | 130.14% | 45.0 | |
 | 127 | Xenetic Biosciences Inc. | | 130.07% | 51.0 | |
 | 128 | SPECTRUM PHARMACEUTICALS INC | | 127.73% | 0.0 |  |
 | 129 | VBI Vaccines Inc BC | | 126.41% | 32.0 | |
 | 130 | MACROGENICS INC | | 124.19% | 29.0 | |
 | 131 | Intra-Cellular Therapies Inc. | | 122.39% | -50.0 | |
 | 132 | AGIOS PHARMACEUTICALS INC. | | 121.20% | -18.0 | |
 | 133 | LIFECORE BIOMEDICAL INC. \DE\ | | 120.96% | -22.0 | |
 | 134 | PERRIGO Co plc | | 120.92% | 21.0 | |
| 135 | NANOVIRICIDES INC. | | 120.37% | -77.0 | |
| 136 | LIXTE BIOTECHNOLOGY HOLDINGS INC. | | 120.03% | -76.0 | |
 | 137 | CHIMERIX INC | | 118.95% | -87.0 | |
 | 138 | VERU INC. | | 116.37% | 60.0 | |
| 139 | Skye Bioscience Inc. | | 115.78% | 215.0 | |
 | 140 | Xenon Pharmaceuticals Inc. | | 114.65% | -63.0 | |
 | 141 | Savara Inc | | 113.22% | 7.0 | |
 | 142 | Zymeworks BC Inc. | | 112.95% | -43.0 | |
 | 143 | Morphic Holding Inc. | | 112.49% | 0.0 | |
 | 144 | MEI Pharma Inc. | | 111.79% | 68.0 | |
 | 145 | CONCERT PHARMACEUTICALS INC. | | 111.13% | -81.0 | |
 | 146 | Emergent BioSolutions Inc. | | 109.61% | 0.0 | |
| 147 | MERRIMACK PHARMACEUTICALS INC | | 108.95% | 32.0 | |
 | 148 | SIGA TECHNOLOGIES INC | | 107.53% | -147.0 | |
 | 149 | CUMBERLAND PHARMACEUTICALS INC | | 106.73% | 27.0 | |
 | 150 | Ocuphire Pharma Inc. | | 106.29% | 82.0 | |
 | 151 | Theravance Biopharma Inc. | | 105.57% | -51.0 | |
 | 152 | ANI PHARMACEUTICALS INC | | 105.55% | 21.0 | |
 | 153 | DURECT CORP | | 104.46% | -41.0 | |
 | 154 | HARROW INC. | | 103.65% | -33.0 | |
 | 155 | Viracta Therapeutics Inc. | | 102.45% | 160.0 | |
 | 156 | Fulcrum Therapeutics Inc. | | 100.54% | 0.0 | |
 | 157 | Revance Therapeutics Inc. | | 100.39% | 47.0 | |
 | 158 | XOMA Corp | | 99.93% | 76.0 | |
 | 159 | VYNE Therapeutics Inc. | | 98.39% | -108.0 | |
 | 160 | Spero Therapeutics Inc. | | 97.89% | -101.0 | |
 | 161 | GYRE THERAPEUTICS INC. | | 96.88% | -135.0 | |
 | 162 | Entasis Therapeutics Holdings Inc. | | 95.69% | -110.0 | |
 | 163 | Phathom Pharmaceuticals Inc. | | 95.64% | 0.0 | |
 | 164 | ALNYLAM PHARMACEUTICALS INC. | | 94.69% | -49.0 | |
 | 165 | Blueprint Medicines Corp | | 94.60% | -36.0 | |
| 166 | ACTAVIA LIFE SCIENCES INC. | | 93.22% | 69.0 | |
 | 167 | LEXICON PHARMACEUTICALS INC. | | 92.32% | 120.0 | |
 | 168 | PFIZER INC | | 92.24% | 19.0 | |
 | 169 | Pacira BioSciences Inc. | | 91.77% | 5.0 | |
| 170 | Strongbridge Biopharma plc | | 91.63% | -92.0 | |
 | 171 | JOHNSON & JOHNSON | | 91.47% | 15.0 | |
 | 172 | KINETA INC. DE | | 89.98% | -68.0 | |
| 173 | ADIAL PHARMACEUTICALS INC. | | 89.80% | 143.0 | |
 | 174 | MUSTANG BIO INC. | | 89.15% | -29.0 | |
 | 175 | CV Sciences Inc. | | 87.96% | -158.0 | |
| 176 | Molecular Templates Inc. | | 87.44% | -60.0 | |
 | 177 | Larimar Therapeutics Inc. | | 86.91% | -33.0 | |
 | 178 | Merus N.V. | | 85.99% | 0.0 | |
 | 179 | RIGEL PHARMACEUTICALS INC | | 83.32% | -48.0 | |
 | 180 | ALBIREO PHARMA INC. | | 83.21% | -39.0 | |
| 181 | Mylan II B.V. | | 81.50% | 19.0 | |
 | 182 | TREVENA INC | | 81.41% | 0.0 | |
| 183 | BIOVIE INC. | | 80.91% | 121.0 | |
 | 184 | AVEO PHARMACEUTICALS INC. | | 80.88% | 124.0 | |
 | 185 | Avalo Therapeutics Inc. | | 78.25% | 77.0 | |
 | 186 | Moleculin Biotech Inc. | | 77.80% | -6.0 | |
 | 187 | ORAMED PHARMACEUTICALS INC. | | 76.11% | -40.0 | |
 | 188 | AMICUS THERAPEUTICS INC. | | 75.89% | 38.0 | |
 | 189 | BIODELIVERY SCIENCES INTERNATIONAL INC | | 70.72% | 59.0 | |
 | 190 | Akebia Therapeutics Inc. | | 69.61% | -55.0 | |
 | 191 | PHIBRO ANIMAL HEALTH CORP | | 68.12% | 18.0 | |
 | 192 | ATOSSA THERAPEUTICS INC. | | 68.11% | 0.0 | |
 | 193 | Cogent Biosciences Inc. | | 67.99% | -43.0 | |
 | 194 | Sonoma Pharmaceuticals Inc. | | 67.83% | -17.0 | |
 | 195 | ONCOSEC MEDICAL Inc | | 65.21% | 61.0 | |
 | 196 | BeiGene Ltd. | | 64.86% | -91.0 | |
 | 197 | CHEMBIO DIAGNOSTICS INC. | | 63.17% | -121.0 | |
 | 198 | KIORA PHARMACEUTICALS INC | | 63.17% | 0.0 | |
 | 199 | Enveric Biosciences Inc. | | 63.16% | 58.0 | |
 | 200 | Zoetis Inc. | | 59.95% | 16.0 | |
 | 201 | Eterna Therapeutics Inc. | | 58.24% | -19.0 | |
 | 202 | BioXcel Therapeutics Inc. | | 57.93% | -122.0 | |
 | 203 | OMEROS CORP | | 57.90% | 77.0 | |
 | 204 | PIERIS PHARMACEUTICALS INC. | | 54.89% | 29.0 | |
 | 205 | Protagonist Therapeutics Inc | | 52.51% | -113.0 | |
 | 206 | Orgenesis Inc. | | 51.89% | -76.0 | |
| 207 | CONTRAFECT Corp | | 51.25% | 0.0 | |
 | 208 | TEVA PHARMACEUTICAL INDUSTRIES LTD | | 50.02% | 14.0 | |
 | 209 | Regulus Therapeutics Inc. | | 49.37% | 110.0 | |
 | 210 | Sarepta Therapeutics Inc. | | 48.97% | -61.0 | |
 | 211 | COLLEGIUM PHARMACEUTICAL INC | | 48.62% | 8.0 | |
 | 212 | Travere Therapeutics Inc. | | 47.58% | -16.0 | |
 | 213 | Aeglea BioTherapeutics Inc. | | 47.28% | -100.0 | |
 | 214 | DiaMedica Therapeutics Inc. | | 46.78% | -169.0 | |
 | 215 | Checkpoint Therapeutics Inc. | | 43.91% | 86.0 | |
 | 216 | OTONOMY INC. | | 39.02% | -74.0 | |
| 217 | Theriva Biologics Inc. | | 38.09% | -131.0 | |
 | 218 | ELI LILLY & Co | | 33.13% | -5.0 | |
 | 219 | ChemoCentryx Inc. | | 33.10% | 44.0 | |
| 220 | Applied Therapeutics Inc. | | 32.94% | 0.0 | |
| 221 | Evelo Biosciences Inc. | | 29.72% | -139.0 | |
 | 222 | LANNETT CO INC | | 29.64% | -27.0 | |
 | 223 | Organogenesis Holdings Inc. | | 28.59% | 27.0 | |
| 224 | Urovant Sciences Ltd. | | 27.72% | 0.0 | |
| 225 | Dicerna Pharmaceuticals Inc | | 27.11% | -31.0 | |
 | 226 | Arcturus Therapeutics Holdings Inc. | | 26.53% | 0.0 | |
 | 227 | Imunon Inc. | | 26.44% | -20.0 | |
 | 228 | INTEGRATED BIOPHARMA INC | | 26.24% | 53.0 | |
 | 229 | Evolus Inc. | | 23.23% | -28.0 | |
 | 230 | ALPINE IMMUNE SCIENCES INC. | | 22.50% | -79.0 | |
| 231 | Cellectar Biosciences Inc. | | 19.29% | -68.0 | |
 | 232 | Acer Therapeutics Inc. | | 17.74% | 0.0 | |
| 233 | AKORN INC | | 14.88% | 9.0 | |
 | 234 | NightHawk Biosciences Inc. | | 12.56% | -116.0 | |
 | 235 | Fortress Biotech Inc. | | 12.15% | 64.0 | |
| 236 | PROGENICS PHARMACEUTICALS INC | | 11.95% | -44.0 | |
 | 237 | CHINOOK THERAPEUTICS INC. | | 11.68% | -17.0 | |
 | 238 | CohBar Inc. | | 10.04% | -66.0 | |
 | 239 | Evoke Pharma Inc | | 9.72% | 28.0 | |
 | 240 | Lexaria Bioscience Corp. | | 8.78% | 83.0 | |
 | 241 | Amneal Pharmaceuticals Inc. | | 3.38% | -12.0 | |
 | 242 | ROCKWELL MEDICAL INC. | | 2.39% | -15.0 | |
| 243 | ZOGENIX INC. | | 0.75% | -205.0 | |
 | 244 | Bausch Health Companies Inc. | | 0.58% | 11.0 | |
 | 245 | Eton Pharmaceuticals Inc. | | -1.47% | 0.0 | |
| 246 | NeuroBo Pharmaceuticals Inc. | | -1.98% | 45.0 | |
 | 247 | OptiNose Inc. | | -2.91% | -37.0 | |
 | 248 | Syndax Pharmaceuticals Inc | | -3.53% | -10.0 | |
 | 249 | CytomX Therapeutics Inc. | | -4.51% | -19.0 | |
 | 250 | Pulmatrix Inc. | | -5.37% | 8.0 | |
| 251 | AILERON THERAPEUTICS INC | | -9.54% | 0.0 | |
 | 252 | EYENOVIA INC. | | -10.91% | -71.0 | |
 | 253 | Jaguar Health Inc. | | -12.10% | 16.0 | |
 | 254 | Lipocine Inc. | | -13.27% | -13.0 | |
| 255 | PORTOLA PHARMACEUTICALS INC | | -13.30% | 34.0 | |
| 256 | Teligent Inc. | | -16.28% | 3.0 | |
 | 257 | RVL Pharmaceuticals plc | | -18.18% | -68.0 | |
 | 258 | PUMA BIOTECHNOLOGY INC. | | -20.13% | 12.0 | |
| 259 | Assertio Therapeutics Inc | | -23.58% | -42.0 | |
 | 260 | Ampio Pharmaceuticals Inc. | | -23.64% | -258.0 | |
 | 261 | CTI BIOPHARMA CORP | | -26.42% | -73.0 | |
 | 262 | Societal CDMO Inc. | | -26.51% | 32.0 | |
 | 263 | CHINA PHARMA HOLDINGS INC. | | -28.06% | -120.0 | |
 | 264 | Wave Life Sciences Ltd. | | -28.34% | -4.0 | |
| 265 | Neos Therapeutics Inc. | | -29.22% | 13.0 | |
 | 266 | Esperion Therapeutics Inc. | | -30.65% | 24.0 | |
 | 267 | International Stem Cell CORP | | -31.05% | -31.0 | |
 | 268 | Sio Gene Therapies Inc. | | -33.81% | 29.0 | |
 | 269 | INTERCEPT PHARMACEUTICALS INC. | | -35.04% | 17.0 | |
 | 270 | Minerva Neurosciences Inc. | | -38.36% | -105.0 | |
 | 271 | Karyopharm Therapeutics Inc. | | -42.16% | -56.0 | |
 | 272 | Aptevo Therapeutics Inc. | | -42.28% | -25.0 | |
 | 273 | iBio Inc. | | -45.55% | -36.0 | |
| 274 | Aimmune Therapeutics Inc. | | -45.60% | -157.0 | |
 | 275 | CYTOKINETICS INC | | -47.55% | -1.0 | |
 | 276 | AYTU BIOPHARMA INC | | -47.92% | -85.0 | |
 | 277 | AVADEL PHARMACEUTICALS PLC | | -50.08% | 0.0 | |
 | 278 | DYNAVAX TECHNOLOGIES CORP | | -50.39% | -6.0 | |
 | 279 | Clearside Biomedical Inc. | | -54.63% | 33.0 | |
 | 280 | ABVC BIOPHARMA INC. | | -57.20% | 73.0 | |
| 281 | VIVUS INC | | -59.49% | -5.0 | |
 | 282 | TherapeuticsMD Inc. | | -61.33% | -36.0 | |
 | 283 | SCYNEXIS INC | | -62.18% | -113.0 | |
| 284 | Bellerophon Therapeutics Inc. | | -62.91% | 0.0 | |
 | 285 | Aclaris Therapeutics Inc. | | -64.89% | -151.0 | |
 | 286 | SELLAS Life Sciences Group Inc. | | -64.97% | 25.0 | |
 | 287 | Zosano Pharma Corp | | -65.00% | 0.0 | |
| 288 | Adamas Pharmaceuticals Inc | | -65.55% | -39.0 | |
 | 289 | RELMADA THERAPEUTICS INC. | | -65.85% | 49.0 | |
 | 290 | Apellis Pharmaceuticals Inc. | | -66.06% | -138.0 | |
 | 291 | Sonnet BioTherapeutics Holdings Inc. | | -70.79% | -52.0 | |
 | 292 | Paratek Pharmaceuticals Inc. | | -72.68% | -27.0 | |
 | 293 | TG THERAPEUTICS INC. | | -74.08% | 24.0 | |
 | 294 | NovaBay Pharmaceuticals Inc. | | -74.39% | -54.0 | |
 | 295 | INFINITY PHARMACEUTICALS INC. | | -74.67% | -246.0 | |
| 296 | Flexion Therapeutics Inc | | -80.97% | -43.0 | |
 | 297 | ImmunoGen Inc. | | -86.00% | -13.0 | |
| 298 | CANNAPHARMARX INC. | | -88.54% | -21.0 | |
 | 299 | Anixa Biosciences Inc | | -91.10% | 15.0 | |
 | 300 | IntelGenx Technologies Corp. | | -91.88% | -76.0 | |
 | 301 | Clovis Oncology Inc. | | -92.54% | -35.0 | |
 | 302 | Aquestive Therapeutics Inc. | | -94.16% | -17.0 | |
 | 303 | Verastem Inc. | | -96.80% | -95.0 | |
 | 304 | SOLIGENIX INC. | | -97.49% | -61.0 | |
 | 305 | Seres Therapeutics Inc. | | -97.95% | 4.0 | |
| 306 | XERIS PHARMACEUTICALS INC | | -99.00% | 0.0 | |
 | 307 | PLx Pharma Winddown Corp. | | -100.48% | -108.0 | |
 | 308 | BELLICUM PHARMACEUTICALS INC | | -101.70% | -64.0 | |
| 309 | First Wave BioPharma Inc. | | -110.62% | -2.0 | |
 | 310 | OCULAR THERAPEUTIX INC | | -114.97% | -56.0 | |
 | 311 | Vistagen Therapeutics Inc. | | -118.58% | -36.0 | |
 | 312 | Carisma Therapeutics Inc. | | -120.13% | -271.0 | |
 | 313 | Statera Biopharma Inc. | | -125.32% | -123.0 | |
| 314 | Tonix Pharmaceuticals Holding Corp. | | -126.13% | -130.0 | |
| 315 | NeuBase Therapeutics Inc. | | -129.15% | 0.0 | |
 | 316 | Corbus Pharmaceuticals Holdings Inc. | | -132.13% | -45.0 | |
 | 317 | Actinium Pharmaceuticals Inc. | | -137.78% | -19.0 | |
| 318 | Intec Pharma Ltd. | | -178.95% | -182.0 | |
| 319 | CQENS Technologies Inc. | | -191.45% | 15.0 | |
 | 320 | MANNKIND CORP | | -200.86% | 2.0 | |
| 321 | Hoth Therapeutics Inc. | | -218.76% | 36.0 | |
 | 322 | MusclePharm Corp | | -234.97% | 0.0 | |
| 323 | PROTEO INC | | -238.45% | -5.0 | |
| 324 | Rezolute Inc. | | -241.14% | 36.0 | |
 | 325 | CEN BIOTECH INC | | -247.09% | 2.0 | |
| 326 | Evofem Biosciences Inc. | | -259.51% | 35.0 | |
| 327 | Genprex Inc. | | -269.69% | -116.0 | |
 | 328 | vTv Therapeutics Inc. | | -271.39% | 8.0 | |
 | 329 | Ainos Inc. | | -274.21% | -65.0 | |
 | 330 | CytoDyn Inc. | | -282.34% | 0.0 | |
| 331 | REGENERX BIOPHARMACEUTICALS INC | | -288.51% | 19.0 | |
| 332 | NORTHWEST BIOTHERAPEUTICS INC | | -308.33% | -6.0 | |
| 333 | CARDAX INC. | | -311.04% | -8.0 | |
| 334 | ZEVRA THERAPEUTICS INC. | | -319.65% | -2.0 | |
| 335 | SANGUI BIOTECH INTERNATIONAL INC | | -361.60% | -2.0 | |
| 336 | Rebus Holdings Inc. | | -363.50% | 1.0 | |
 | 337 | Qualigen Therapeutics Inc. | | -366.73% | -76.0 | |
 | 338 | Iterum Therapeutics plc | | -381.42% | -135.0 | |
| 339 | GlobeStar Therapeutics Corp | | -382.45% | 9.0 | |
| 340 | ENDONOVO THERAPEUTICS INC. | | -388.73% | -12.0 | |
 | 341 | Biostax Corp. | | -393.29% | 15.0 | |
| 342 | RespireRx Pharmaceuticals Inc. | | -396.00% | 7.0 | |
 | 343 | GeoVax Labs Inc. | | -404.32% | 2.0 | |
 | 344 | LEAP THERAPEUTICS INC. | | -432.82% | -62.0 | |
| 345 | NANOMIX Corp | | -441.89% | -10.0 | |
 | 346 | HUMANIGEN INC | | -454.58% | 9.0 | |
 | 347 | SEELOS THERAPEUTICS INC. | | -461.89% | -27.0 | |
| 348 | Earth Science Tech Inc. | | -499.77% | 0.0 | |
| 349 | Greater Cannabis Company Inc. | | -521.66% | 0.0 | |
| 350 | BIOXYTRAN INC | | -522.11% | 2.0 | |
 | 351 | Adhera Therapeutics Inc. | | -540.39% | -12.0 | |
| 352 | Propanc Biopharma Inc. | | -568.40% | 6.0 | |
| 353 | Q BioMed Inc. | | -599.37% | -22.0 | |
| 354 | Wellness Center USA Inc. | | -600.04% | 8.0 | |
 | 355 | VACCINEX INC. | | -623.14% | -87.0 | |
 | 356 | One World Products Inc. | | -674.85% | 7.0 | |
| 357 | ProtoKinetix Inc. | | -1057.86% | -10.0 | |
| 358 | NEXIEN BIOPHARMA INC. | | -2162.81% | -191.0 | |
