| 1 | BIOSPECIFICS TECHNOLOGIES CORP | | 357.51% | 0.0 | |
| 2 | SPRING PHARMACEUTICAL GROUP INC. | | 355.04% | 0.0 | |
| 3 | ENANTA PHARMACEUTICALS INC | | 332.14% | 0.0 | |
| 4 | Jazz Pharmaceuticals plc | | 323.69% | 0.0 | |
| 5 | Carisma Therapeutics Inc. | | 322.16% | 0.0 | |
| 6 | EAGLE PHARMACEUTICALS INC. | | 297.41% | 0.0 | |
| 7 | ACHILLION PHARMACEUTICALS INC | | 292.07% | 0.0 | |
| 8 | UNITED THERAPEUTICS Corp | | 281.00% | 0.0 | |
| 9 | VERU INC. | | 271.09% | 0.0 | |
| 10 | AbbVie Inc. | | 270.97% | 0.0 | |
| 11 | ABBOTT LABORATORIES | | 270.46% | 0.0 | |
| 12 | Catalent Inc. | | 269.32% | 0.0 | |
| 13 | CHIMERIX INC | | 268.32% | 0.0 | |
| 14 | Aclaris Therapeutics Inc. | | 266.46% | 0.0 | |
| 15 | FIVE PRIME THERAPEUTICS INC. | | 262.30% | 0.0 | |
| 16 | GERON CORP | | 262.15% | 0.0 | |
| 17 | Corvus Pharmaceuticals Inc. | | 260.40% | 0.0 | |
| 18 | Neoleukin Therapeutics Inc. | | 258.24% | 0.0 | |
| 19 | ENDOCYTE INC | | 256.30% | 0.0 | |
| 20 | Ra Pharmaceuticals Inc. | | 253.29% | 0.0 | |
| 21 | China Health Industries Holdings Inc. | | 249.76% | 0.0 | |
| 22 | Merck & Co. Inc. | | 244.89% | 0.0 | |
| 23 | Moleculin Biotech Inc. | | 244.66% | 0.0 | |
| 24 | Xenon Pharmaceuticals Inc. | | 244.57% | 0.0 | |
| 25 | Aeglea BioTherapeutics Inc. | | 243.40% | 0.0 | |
| 26 | Esperion Therapeutics Inc. | | 243.20% | 0.0 | |
| 27 | AMICUS THERAPEUTICS INC. | | 242.82% | 0.0 | |
| 28 | ABEONA THERAPEUTICS INC. | | 241.55% | 0.0 | |
| 29 | Theravance Biopharma Inc. | | 239.36% | 0.0 | |
| 30 | Edesa Biotech Inc. | | 238.24% | 0.0 | |
| 31 | Blueprint Medicines Corp | | 234.41% | 0.0 | |
| 32 | ZOGENIX INC. | | 233.15% | 0.0 | |
| 33 | ALDER BIOPHARMACEUTICALS INC | | 230.69% | 0.0 | |
| 34 | MACROGENICS INC | | 228.24% | 0.0 | |
| 35 | SYNLOGIC INC. | | 228.11% | 0.0 | |
| 36 | Pfenex Inc. | | 227.33% | 0.0 | |
| 37 | ROCKWELL MEDICAL INC. | | 226.75% | 0.0 | |
| 38 | CATALYST PHARMACEUTICALS INC. | | 224.64% | 0.0 | |
| 39 | Assertio Therapeutics Inc | | 224.16% | 0.0 | |
| 40 | CUMBERLAND PHARMACEUTICALS INC | | 219.48% | 0.0 | |
| 41 | Adamas Pharmaceuticals Inc | | 219.01% | 0.0 | |
| 42 | Amphastar Pharmaceuticals Inc. | | 218.82% | 0.0 | |
| 43 | MEDICINOVA INC | | 215.25% | 0.0 | |
| 44 | Larimar Therapeutics Inc. | | 214.19% | 0.0 | |
| 45 | BeiGene Ltd. | | 212.86% | 0.0 | |
| 46 | Epizyme Inc. | | 209.26% | 0.0 | |
| 47 | OPKO HEALTH INC. | | 207.51% | 0.0 | |
| 48 | Xencor Inc | | 207.36% | 0.0 | |
| 49 | Intra-Cellular Therapies Inc. | | 205.92% | 0.0 | |
| 50 | ACADIA PHARMACEUTICALS INC | | 205.44% | 0.0 | |
| 51 | KINETA INC. DE | | 204.04% | 0.0 | |
| 52 | Statera Biopharma Inc. | | 203.49% | 0.0 | |
| 53 | Wave Life Sciences Ltd. | | 203.27% | 0.0 | |
| 54 | AGIOS PHARMACEUTICALS INC. | | 201.91% | 0.0 | |
| 55 | Cellectar Biosciences Inc. | | 199.99% | 0.0 | |
| 56 | TENAX THERAPEUTICS INC. | | 199.24% | 0.0 | |
| 57 | Clearside Biomedical Inc. | | 198.77% | 0.0 | |
| 58 | Endo International plc | | 197.40% | 0.0 | |
| 59 | SUPERNUS PHARMACEUTICALS INC. | | 197.12% | 0.0 | |
| 60 | OTONOMY INC. | | 196.84% | 0.0 | |
| 61 | JUNIPER PHARMACEUTICALS INC | | 196.12% | 0.0 | |
| 62 | Neurotrope Inc. | | 195.38% | 0.0 | |
| 63 | VBI Vaccines Inc BC | | 190.33% | 0.0 | |
| 64 | MUSTANG BIO INC. | | 189.45% | 0.0 | |
| 65 | Minerva Neurosciences Inc. | | 189.17% | 0.0 | |
| 66 | CAMBREX CORP | | 189.17% | 0.0 | |
| 67 | ARDELYX INC. | | 188.58% | 0.0 | |
| 68 | Flexion Therapeutics Inc | | 188.19% | 0.0 | |
| 69 | ALPINE IMMUNE SCIENCES INC. | | 186.68% | 0.0 | |
| 70 | Revance Therapeutics Inc. | | 185.88% | 0.0 | |
| 71 | MyoKardia Inc. | | 184.20% | 0.0 | |
| 72 | Syros Pharmaceuticals Inc. | | 184.12% | 0.0 | |
| 73 | ALIMERA SCIENCES INC | | 181.13% | 0.0 | |
| 74 | Lipocine Inc. | | 179.91% | 0.0 | |
| 75 | REGENERON PHARMACEUTICALS INC. | | 179.78% | 0.0 | |
| 76 | Dermira Inc. | | 178.02% | 0.0 | |
| 77 | ALEXION PHARMACEUTICALS INC. | | 172.38% | 0.0 | |
| 78 | CASSAVA SCIENCES INC | | 172.34% | 0.0 | |
| 79 | Kura Oncology Inc. | | 169.88% | 0.0 | |
| 80 | CohBar Inc. | | 169.64% | 0.0 | |
| 81 | PROTHENA CORP PUBLIC LTD CO | | 168.93% | 0.0 | |
| 82 | AGILE THERAPEUTICS INC | | 168.34% | 0.0 | |
| 83 | CONCERT PHARMACEUTICALS INC. | | 167.54% | 0.0 | |
| 84 | Checkpoint Therapeutics Inc. | | 166.98% | 0.0 | |
| 85 | RELIV INTERNATIONAL INC | | 165.43% | 0.0 | |
| 86 | CORCEPT THERAPEUTICS INC | | 165.02% | 0.0 | |
| 87 | TherapeuticsMD Inc. | | 164.37% | 0.0 | |
| 88 | IMMUNE DESIGN CORP. | | 164.35% | 0.0 | |
| 89 | NATURES SUNSHINE PRODUCTS INC | | 163.87% | 0.0 | |
| 90 | Allergan plc | | 160.39% | 0.0 | |
| 91 | Calithera Biosciences Inc. | | 160.38% | 0.0 | |
| 92 | Emergent BioSolutions Inc. | | 160.18% | 0.0 | |
| 93 | CHIASMA INC | | 160.17% | 0.0 | |
| 94 | Ocuphire Pharma Inc. | | 160.08% | 0.0 | |
| 95 | LIGAND PHARMACEUTICALS INC | | 152.62% | 0.0 | |
| 96 | ALBIREO PHARMA INC. | | 152.49% | 0.0 | |
| 97 | Tempest Therapeutics Inc. | | 151.87% | 0.0 | |
| 98 | Citius Pharmaceuticals Inc. | | 151.41% | 0.0 | |
| 99 | Syndax Pharmaceuticals Inc | | 149.77% | 0.0 | |
| 100 | LIFECORE BIOMEDICAL INC. \DE\ | | 149.05% | 0.0 | |
| 101 | COLLEGIUM PHARMACEUTICAL INC | | 145.79% | 0.0 | |
| 102 | CYTOKINETICS INC | | 145.37% | 0.0 | |
| 103 | NeuroBo Pharmaceuticals Inc. | | 144.76% | 0.0 | |
| 104 | SOLIGENIX INC. | | 144.29% | 0.0 | |
| 105 | ALNYLAM PHARMACEUTICALS INC. | | 143.74% | 0.0 | |
| 106 | Vanda Pharmaceuticals Inc. | | 143.66% | 0.0 | |
| 107 | Nabriva Therapeutics plc | | 142.85% | 0.0 | |
| 108 | RELMADA THERAPEUTICS INC. | | 135.93% | 0.0 | |
| 109 | CHEMBIO DIAGNOSTICS INC. | | 134.98% | 0.0 | |
| 110 | ARENA PHARMACEUTICALS INC | | 134.97% | 0.0 | |
| 111 | INFINITY PHARMACEUTICALS INC. | | 132.30% | 0.0 | |
| 112 | Travere Therapeutics Inc. | | 129.66% | 0.0 | |
| 113 | Sio Gene Therapies Inc. | | 129.08% | 0.0 | |
| 114 | XBiotech Inc. | | 127.78% | 0.0 | |
| 115 | BRISTOL MYERS SQUIBB CO | | 127.60% | 0.0 | |
| 116 | Zynerba Pharmaceuticals Inc. | | 126.38% | 0.0 | |
| 117 | Aravive Inc. | | 126.00% | 0.0 | |
| 118 | ANI PHARMACEUTICALS INC | | 124.24% | 0.0 | |
| 119 | TESARO Inc. | | 123.98% | 0.0 | |
| 120 | Sarepta Therapeutics Inc. | | 121.93% | 0.0 | |
| 121 | Phio Pharmaceuticals Corp. | | 121.42% | 0.0 | |
| 122 | Ayala Pharmaceuticals Inc. | | 120.34% | 0.0 | |
| 123 | GLYCOMIMETICS INC | | 116.86% | 0.0 | |
| 124 | BELLICUM PHARMACEUTICALS INC | | 115.66% | 0.0 | |
| 125 | NANOVIRICIDES INC. | | 115.17% | 0.0 | |
| 126 | ARATANA THERAPEUTICS INC. | | 114.54% | 0.0 | |
| 127 | ORAMED PHARMACEUTICALS INC. | | 113.86% | 0.0 | |
| 128 | Oncternal Therapeutics Inc. | | 113.27% | 0.0 | |
| 129 | SPECTRUM PHARMACEUTICALS INC | | 109.19% | 0.0 | |
| 130 | Evofem Biosciences Inc. | | 108.97% | 0.0 | |
| 131 | Altimmune Inc. | | 105.73% | 0.0 | |
| 132 | AKORN INC | | 101.71% | 0.0 | |
| 133 | Achaogen Inc. | | 101.65% | 0.0 | |
| 134 | ARROWHEAD PHARMACEUTICALS INC. | | 101.40% | 0.0 | |
| 135 | VERTEX PHARMACEUTICALS INC MA | | 99.35% | 0.0 | |
| 136 | DMK PHARMACEUTICALS Corp | | 95.62% | 0.0 | |
| 137 | CHINOOK THERAPEUTICS INC. | | 92.00% | 0.0 | |
| 138 | BIO-PATH HOLDINGS INC | | 91.91% | 0.0 | |
| 139 | OCULAR THERAPEUTIX INC | | 91.51% | 0.0 | |
| 140 | PIERIS PHARMACEUTICALS INC. | | 91.21% | 0.0 | |
| 141 | International Stem Cell CORP | | 91.01% | 0.0 | |
| 142 | ROCKET PHARMACEUTICALS INC. | | 89.16% | 0.0 | |
| 143 | ARQULE INC | | 87.69% | 0.0 | |
| 144 | ELI LILLY & Co | | 83.84% | 0.0 | |
| 145 | Sonoma Pharmaceuticals Inc. | | 83.35% | 0.0 | |
| 146 | iBio Inc. | | 77.56% | 0.0 | |
| 147 | Matinas BioPharma Holdings Inc. | | 75.29% | 0.0 | |
| 148 | Histogen Inc. | | 71.90% | 0.0 | |
| 149 | CV Sciences Inc. | | 71.54% | 0.0 | |
| 150 | Molecular Templates Inc. | | 70.60% | 0.0 | |
| 151 | SCYNEXIS INC | | 70.55% | 0.0 | |
| 152 | ELITE PHARMACEUTICALS INC NV | | 70.42% | 0.0 | |
| 153 | IntelGenx Technologies Corp. | | 69.58% | 0.0 | |
| 154 | LANNETT CO INC | | 67.16% | 0.0 | |
| 155 | Seres Therapeutics Inc. | | 66.14% | 0.0 | |
| 156 | F-star Therapeutics Inc. | | 64.84% | 0.0 | |
| 157 | Viracta Therapeutics Inc. | | 64.68% | 0.0 | |
| 158 | Societal CDMO Inc. | | 63.16% | 0.0 | |
| 159 | DYNAVAX TECHNOLOGIES CORP | | 62.44% | 0.0 | |
| 160 | Lifevantage Corp | | 61.17% | 0.0 | |
| 161 | SOPHIRIS BIO INC. | | 59.00% | 0.0 | |
| 162 | PUMA BIOTECHNOLOGY INC. | | 57.45% | 0.0 | |
| 163 | PERRIGO Co plc | | 56.94% | 0.0 | |
| 164 | Fortress Biotech Inc. | | 55.25% | 0.0 | |
| 165 | Teligent Inc. | | 54.71% | 0.0 | |
| 166 | Astria Therapeutics Inc. | | 54.42% | 0.0 | |
| 167 | CELGENE CORP DE | | 53.16% | 0.0 | |
| 168 | OMEROS CORP | | 51.18% | 0.0 | |
| 169 | SELLAS Life Sciences Group Inc. | | 50.00% | 0.0 | |
| 170 | BIOMARIN PHARMACEUTICAL INC | | 49.91% | 0.0 | |
| 171 | Zoetis Inc. | | 49.41% | 0.0 | |
| 172 | Actinium Pharmaceuticals Inc. | | 49.19% | 0.0 | |
| 173 | CytomX Therapeutics Inc. | | 47.60% | 0.0 | |
| 174 | CorMedix Inc. | | 46.21% | 0.0 | |
| 175 | PLx Pharma Winddown Corp. | | 46.07% | 0.0 | |
| 176 | TREVENA INC | | 42.82% | 0.0 | |
| 177 | PHIBRO ANIMAL HEALTH CORP | | 41.28% | 0.0 | |
| 178 | MARINUS PHARMACEUTICALS INC. | | 40.09% | 0.0 | |
| 179 | Impax Laboratories LLC | | 39.87% | 0.0 | |
| 180 | Avid Bioservices Inc. | | 39.46% | 0.0 | |
| 181 | Sonnet BioTherapeutics Holdings Inc. | | 36.89% | 0.0 | |
| 182 | Axsome Therapeutics Inc. | | 36.10% | 0.0 | |
| 183 | GYRE THERAPEUTICS INC. | | 35.59% | 0.0 | |
| 184 | ChemoCentryx Inc. | | 35.01% | 0.0 | |
| 185 | Bellerophon Therapeutics Inc. | | 34.49% | 0.0 | |
| 186 | Tonix Pharmaceuticals Holding Corp. | | 32.26% | 0.0 | |
| 187 | Orgenesis Inc. | | 32.06% | 0.0 | |
| 188 | Eterna Therapeutics Inc. | | 27.96% | 0.0 | |
| 189 | PORTOLA PHARMACEUTICALS INC | | 25.46% | 0.0 | |
| 190 | Old API Wind-down Ltd. | | 22.93% | 0.0 | |
| 191 | uniQure N.V. | | 22.85% | 0.0 | |
| 192 | INTERCEPT PHARMACEUTICALS INC. | | 22.15% | 0.0 | |
| 193 | Regulus Therapeutics Inc. | | 20.13% | 0.0 | |
| 194 | VIVUS INC | | 18.34% | 0.0 | |
| 195 | AVADEL PHARMACEUTICALS PLC | | 13.65% | 0.0 | |
| 196 | Fibrocell Science Inc. | | 12.48% | 0.0 | |
| 197 | Paratek Pharmaceuticals Inc. | | 11.50% | 0.0 | |
| 198 | IONIS PHARMACEUTICALS INC | | 8.84% | 0.0 | |
| 199 | Rezolute Inc. | | 2.36% | 0.0 | |
| 200 | Mirati Therapeutics Inc. | | -0.10% | 0.0 | |
| 201 | NEKTAR THERAPEUTICS | | -0.39% | 0.0 | |
| 202 | vTv Therapeutics Inc. | | -2.72% | 0.0 | |
| 203 | SteadyMed Ltd. | | -5.97% | 0.0 | |
| 204 | Akebia Therapeutics Inc. | | -6.99% | 0.0 | |
| 205 | NovaBay Pharmaceuticals Inc. | | -7.92% | 0.0 | |
| 206 | Viking Therapeutics Inc. | | -8.54% | 0.0 | |
| 207 | Capstone Therapeutics Corp. | | -13.30% | 0.0 | |
| 208 | ATHERSYS INC NEW | | -15.93% | 0.0 | |
| 209 | NVN Liquidation Inc. | | -16.96% | 0.0 | |
| 210 | NightHawk Biosciences Inc. | | -18.31% | 0.0 | |
| 211 | Arbutus Biopharma Corp | | -20.06% | 0.0 | |
| 212 | MusclePharm Corp | | -32.48% | 0.0 | |
| 213 | HARROW INC. | | -33.39% | 0.0 | |
| 214 | Corbus Pharmaceuticals Holdings Inc. | | -34.68% | 0.0 | |
| 215 | 9 METERS BIOPHARMA INC. | | -37.04% | 0.0 | |
| 216 | DURECT CORP | | -41.24% | 0.0 | |
| 217 | TG THERAPEUTICS INC. | | -44.94% | 0.0 | |
| 218 | Corium International Inc. | | -48.38% | 0.0 | |
| 219 | Altrazeal Life Sciences Inc. | | -49.38% | 0.0 | |
| 220 | Onconova Therapeutics Inc. | | -52.51% | 0.0 | |
| 221 | Dare Bioscience Inc. | | -53.82% | 0.0 | |
| 222 | ZEVRA THERAPEUTICS INC. | | -54.84% | 0.0 | |
| 223 | AYTU BIOPHARMA INC | | -56.13% | 0.0 | |
| 224 | AMARIN CORP PLC\UK | | -59.42% | 0.0 | |
| 225 | CTI BIOPHARMA CORP | | -65.02% | 0.0 | |
| 226 | OncoMed Pharmaceuticals Inc | | -68.89% | 0.0 | |
| 227 | ACURA PHARMACEUTICALS INC | | -69.86% | 0.0 | |
| 228 | Zyla Life Sciences | | -72.55% | 0.0 | |
| 229 | INTEGRATED BIOPHARMA INC | | -73.24% | 0.0 | |
| 230 | Ampio Pharmaceuticals Inc. | | -75.42% | 0.0 | |
| 231 | Innovation Pharmaceuticals Inc. | | -77.83% | 0.0 | |
| 232 | EOM Pharmaceutical Holdings Inc. | | -83.47% | 0.0 | |
| 233 | ARRAY BIOPHARMA INC | | -84.15% | 0.0 | |
| 234 | ImmunoGen Inc. | | -84.23% | 0.0 | |
| 235 | MANNKIND CORP | | -95.60% | 0.0 | |
| 236 | Clovis Oncology Inc. | | -97.02% | 0.0 | |
| 237 | Pulmatrix Inc. | | -104.00% | 0.0 | |
| 238 | Cryoport Inc. | | -105.14% | 0.0 | |
| 239 | Neos Therapeutics Inc. | | -106.28% | 0.0 | |
| 240 | AVEO PHARMACEUTICALS INC. | | -106.88% | 0.0 | |
| 241 | Theriva Biologics Inc. | | -111.98% | 0.0 | |
| 242 | MABVAX THERAPEUTICS HOLDINGS INC. | | -115.10% | 0.0 | |
| 243 | Zosano Pharma Corp | | -118.51% | 0.0 | |
| 244 | ORAGENICS INC | | -120.17% | 0.0 | |
| 245 | KERYX BIOPHARMACEUTICALS INC | | -120.48% | 0.0 | |
| 246 | GT Biopharma Inc. | | -121.39% | 0.0 | |
| 247 | KIORA PHARMACEUTICALS INC | | -140.55% | 0.0 | |
| 248 | Savara Inc | | -148.02% | 0.0 | |
| 249 | HypGen Inc | | -148.70% | 0.0 | |
| 250 | SIGA TECHNOLOGIES INC | | -175.28% | 0.0 | |
| 251 | PROTEO INC | | -180.51% | 0.0 | |
| 252 | NORTHWEST BIOTHERAPEUTICS INC | | -188.66% | 0.0 | |
| 253 | Anthera Pharmaceuticals Inc | | -196.08% | 0.0 | |
| 254 | Lexaria Bioscience Corp. | | -215.45% | 0.0 | |
| 255 | Qualigen Therapeutics Inc. | | -218.45% | 0.0 | |
| 256 | ProtoKinetix Inc. | | -228.18% | 0.0 | |
| 257 | CQENS Technologies Inc. | | -237.11% | 0.0 | |
| 258 | Ainos Inc. | | -237.78% | 0.0 | |
| 259 | RENOVARO BIOSCIENCES INC. | | -238.04% | 0.0 | |
| 260 | SEELOS THERAPEUTICS INC. | | -240.73% | 0.0 | |
| 261 | XOMA Corp | | -257.70% | 0.0 | |
| 262 | REGENERX BIOPHARMACEUTICALS INC | | -261.97% | 0.0 | |
| 263 | HERON THERAPEUTICS INC. DE | | -268.46% | 0.0 | |
| 264 | MERRIMACK PHARMACEUTICALS INC | | -282.56% | 0.0 | |
| 265 | CEN BIOTECH INC | | -283.69% | 0.0 | |
| 266 | NANOMIX Corp | | -307.04% | 0.0 | |
| 267 | CARDAX INC. | | -314.36% | 0.0 | |
| 268 | NEUROPATHIX INC. | | -333.35% | 0.0 | |
| 269 | Aadi Bioscience Inc. | | -365.91% | 0.0 | |
| 270 | OPIANT PHARMACEUTICALS INC. | | -375.66% | 0.0 | |
| 271 | Health-Right Discoveries Inc. | | -383.95% | 0.0 | |
| 272 | Rebus Holdings Inc. | | -386.07% | 0.0 | |
| 273 | Jaguar Health Inc. | | -395.70% | 0.0 | |
| 274 | Q BioMed Inc. | | -429.10% | 0.0 | |
| 275 | Emmaus Life Sciences Inc. | | -440.65% | 0.0 | |
| 276 | PROVECTUS BIOPHARMACEUTICALS INC. | | -476.22% | 0.0 | |
| 277 | Kaya Holdings Inc. | | -502.50% | 0.0 | |
| 278 | ARTELO BIOSCIENCES INC. | | -509.30% | 0.0 | |
| 279 | ACTAVIA LIFE SCIENCES INC. | | -512.43% | 0.0 | |
| 280 | Skye Bioscience Inc. | | -536.33% | 0.0 | |
| 281 | LIXTE BIOTECHNOLOGY HOLDINGS INC. | | -541.47% | 0.0 | |
| 282 | GeoVax Labs Inc. | | -583.28% | 0.0 | |
| 283 | BIOXYTRAN INC | | -607.50% | 0.0 | |
| 284 | RespireRx Pharmaceuticals Inc. | | -626.68% | 0.0 | |
| 285 | ABVC BIOPHARMA INC. | | -652.82% | 0.0 | |
| 286 | Biostax Corp. | | -765.59% | 0.0 | |
| 287 | Propanc Biopharma Inc. | | -830.88% | 0.0 | |
| 288 | United Cannabis Corp | | -894.55% | 0.0 | |
| 289 | Regen BioPharma Inc | | -1429.50% | 0.0 | |
| 290 | Guardion Health Sciences Inc. | | -1458.67% | 0.0 | |
| 291 | Vistagen Therapeutics Inc. | | -2111.90% | 0.0 | |
| 292 | Oncolix Inc. | | -4571.69% | 0.0 | |