 | 1 | Sage Therapeutics Inc. |  | 371.31% | 108.0 |  |
 | 2 | CATALYST PHARMACEUTICALS INC. | | 340.94% | 21.0 | |
 | 3 | SIGA TECHNOLOGIES INC | | 329.18% | 145.0 | |
 | 4 | XBiotech Inc. | | 328.34% | -3.0 |  |
 | 5 | CORCEPT THERAPEUTICS INC | | 324.53% | 3.0 |  |
 | 6 | CASSAVA SCIENCES INC | | 315.87% | 16.0 | |
 | 7 | ALX ONCOLOGY HOLDINGS INC | | 313.66% | 0.0 |  |
 | 8 | PMV Pharmaceuticals Inc. | | 313.63% | 0.0 | |
 | 9 | Greenwich LifeSciences Inc. | | 307.26% | 0.0 | |
 | 10 | ANAPTYSBIO INC | | 303.54% | 15.0 | |
 | 11 | Turning Point Therapeutics Inc. | | 302.45% | 0.0 | |
 | 12 | Aadi Bioscience Inc. | | 298.11% | 69.0 | |
 | 13 | Minerva Neurosciences Inc. | | 295.64% | 257.0 | |
 | 14 | MARIZYME INC. | | 294.81% | -8.0 |  |
 | 15 | NextCure Inc. | | 293.51% | 9.0 | |
 | 16 | Keros Therapeutics Inc. | | 292.10% | 0.0 | |
| 17 | Dyne Therapeutics Inc. | | 290.65% | 0.0 | |
 | 18 | ENANTA PHARMACEUTICALS INC | | 289.45% | -11.0 | |
 | 19 | Jazz Pharmaceuticals plc | | 289.32% | -10.0 | |
 | 20 | PLIANT THERAPEUTICS INC. | | 289.18% | 0.0 | |
| 21 | RENOVARO BIOSCIENCES INC. | | 289.13% | -7.0 | |
 | 22 | Blueprint Medicines Corp | | 288.92% | 143.0 | |
 | 23 | Karuna Therapeutics Inc. | | 288.74% | -13.0 | |
| 24 | Stoke Therapeutics Inc. | | 283.96% | -11.0 | |
| 25 | Viking Therapeutics Inc. | | 283.44% | -14.0 | |
| 26 | Kura Oncology Inc. | | 281.19% | 12.0 | |
| 27 | MERRIMACK PHARMACEUTICALS INC | | 279.29% | 120.0 | |
| 28 | ESSA Pharma Inc. | | 275.57% | 0.0 | |
 | 29 | LUMOS PHARMA INC. | | 275.41% | 0.0 | |
 | 30 | MEDICINOVA INC | | 273.75% | -11.0 | |
 | 31 | Akouos Inc. | | 272.78% | 0.0 | |
 | 32 | Avidity Biosciences Inc. | | 266.80% | 0.0 | |
 | 33 | Lantern Pharma Inc. | | 266.16% | 0.0 | |
 | 34 | Endo International plc | | 265.50% | 2.0 | |
 | 35 | Prelude Therapeutics Inc | | 262.15% | 0.0 | |
 | 36 | Vanda Pharmaceuticals Inc. | | 261.70% | -20.0 | |
| 37 | Nkarta Inc. | | 260.47% | 0.0 | |
 | 38 | NightHawk Biosciences Inc. | | 259.39% | 196.0 | |
 | 39 | Aptinyx Inc. | | 258.73% | 17.0 | |
 | 40 | Vincerx Pharma Inc. | | 257.65% | 0.0 | |
 | 41 | DURECT CORP | | 257.37% | 112.0 | |
 | 42 | ABBOTT LABORATORIES | | 257.08% | -15.0 | |
 | 43 | Xenon Pharmaceuticals Inc. | | 256.88% | 97.0 | |
 | 44 | Altimmune Inc. | | 256.82% | 31.0 | |
 | 45 | Shattuck Labs Inc. | | 255.75% | 0.0 | |
 | 46 | Kronos Bio Inc. | | 255.10% | 0.0 | |
| 47 | Cellectar Biosciences Inc. | | 253.19% | 184.0 | |
| 48 | FIVE PRIME THERAPEUTICS INC. | | 253.17% | 45.0 | |
 | 49 | China Health Industries Holdings Inc. | | 250.85% | -15.0 | |
| 50 | Metacrine Inc. | | 249.46% | 0.0 | |
 | 51 | Mirati Therapeutics Inc. | | 249.15% | 25.0 | |
 | 52 | ARVINAS INC. | | 248.73% | 39.0 | |
| 53 | ARENA PHARMACEUTICALS INC | | 247.14% | -51.0 | |
 | 54 | Cogent Biosciences Inc. | | 246.15% | 139.0 | |
 | 55 | ARROWHEAD PHARMACEUTICALS INC. | | 243.44% | -3.0 | |
 | 56 | GeoVax Labs Inc. | | 240.67% | 287.0 | |
 | 57 | AbbVie Inc. | | 239.40% | -28.0 | |
| 58 | Corvus Pharmaceuticals Inc. | | 238.78% | 46.0 | |
| 59 | Inozyme Pharma Inc. | | 238.63% | 0.0 | |
 | 60 | VERTEX PHARMACEUTICALS INC MA | | 237.83% | -13.0 | |
 | 61 | BODY & MIND INC. | | 237.67% | 0.0 | |
 | 62 | CymaBay Therapeutics Inc. | | 235.76% | 6.0 | |
 | 63 | BioXcel Therapeutics Inc. | | 234.46% | 139.0 | |
 | 64 | Actinium Pharmaceuticals Inc. | | 232.96% | 253.0 | |
 | 65 | Intra-Cellular Therapies Inc. | | 232.20% | 66.0 | |
 | 66 | Aurinia Pharmaceuticals Inc. | | 230.44% | 0.0 | |
 | 67 | Monopar Therapeutics | | 229.28% | -35.0 | |
 | 68 | Zentalis Pharmaceuticals Inc. | | 228.91% | 0.0 | |
 | 69 | TFF Pharmaceuticals Inc. | | 228.38% | -30.0 | |
 | 70 | KalVista Pharmaceuticals Inc. | | 226.96% | -13.0 | |
 | 71 | Verona Pharma plc | | 225.13% | 0.0 | |
 | 72 | Protagonist Therapeutics Inc | | 224.68% | 133.0 | |
| 73 | Immunome Inc. | | 223.36% | 0.0 | |
 | 74 | Matinas BioPharma Holdings Inc. | | 223.22% | 21.0 | |
 | 75 | Salarius Pharmaceuticals Inc. | | 222.06% | 50.0 | |
| 76 | Genprex Inc. | | 221.47% | 251.0 | |
 | 77 | PROCYON CORP | | 220.33% | -47.0 | |
 | 78 | Xencor Inc | | 219.35% | -60.0 | |
 | 79 | Arcturus Therapeutics Holdings Inc. | | 219.26% | 147.0 | |
 | 80 | Atreca Inc. | | 218.49% | -47.0 | |
 | 81 | UNITED THERAPEUTICS Corp | | 217.82% | -7.0 | |
 | 82 | ASSEMBLY BIOSCIENCES INC. | | 215.76% | -5.0 | |
| 83 | GW PHARMACEUTICALS PLC | | 215.14% | -46.0 | |
| 84 | Applied Molecular Transport Inc. | | 215.10% | 0.0 | |
 | 85 | DiaMedica Therapeutics Inc. | | 215.07% | 129.0 | |
 | 86 | GLYCOMIMETICS INC | | 214.71% | -44.0 | |
 | 87 | ROCKET PHARMACEUTICALS INC. | | 214.21% | -29.0 | |
| 88 | Enliven Therapeutics Inc. | | 213.58% | 0.0 | |
 | 89 | BIOMARIN PHARMACEUTICAL INC | | 208.25% | 1.0 | |
 | 90 | EAGLE PHARMACEUTICALS INC. | | 207.22% | -23.0 | |
 | 91 | Syndax Pharmaceuticals Inc | | 206.63% | 157.0 | |
 | 92 | Repare Therapeutics Inc. | | 205.89% | 0.0 | |
 | 93 | VBI Vaccines Inc BC | | 202.49% | 36.0 | |
 | 94 | IVERIC bio Inc. | | 202.48% | -30.0 | |
| 95 | Arcutis Biotherapeutics Inc. | | 202.38% | 0.0 | |
 | 96 | NGM BIOPHARMACEUTICALS INC | | 200.60% | -61.0 | |
 | 97 | TREVENA INC | | 197.57% | 85.0 | |
 | 98 | Merck & Co. Inc. | | 197.42% | -50.0 | |
 | 99 | XOMA Corp | | 197.32% | 59.0 | |
| 100 | LIXTE BIOTECHNOLOGY HOLDINGS INC. | | 196.72% | 36.0 | |
| 101 | NeuBase Therapeutics Inc. | | 193.87% | 214.0 | |
 | 102 | Kiniksa Pharmaceuticals Ltd. | | 193.86% | -1.0 | |
 | 103 | Syros Pharmaceuticals Inc. | | 193.80% | -4.0 | |
 | 104 | ALIMERA SCIENCES INC | | 193.55% | -20.0 | |
 | 105 | REGENERON PHARMACEUTICALS INC. | | 192.96% | -65.0 | |
 | 106 | Dianthus Therapeutics Inc. DE | | 192.46% | -26.0 | |
 | 107 | Mersana Therapeutics Inc. | | 190.93% | -2.0 | |
 | 108 | Amphastar Pharmaceuticals Inc. | | 190.12% | -53.0 | |
 | 109 | CHINOOK THERAPEUTICS INC. | | 188.75% | 128.0 | |
 | 110 | RAPT Therapeutics Inc. | | 188.69% | 0.0 | |
 | 111 | Larimar Therapeutics Inc. | | 186.81% | 66.0 | |
 | 112 | RELMADA THERAPEUTICS INC. | | 186.78% | 177.0 | |
 | 113 | ChemoCentryx Inc. | | 186.39% | 106.0 | |
| 114 | Tonix Pharmaceuticals Holding Corp. | | 184.48% | 200.0 | |
| 115 | NANOVIRICIDES INC. | | 183.94% | 20.0 | |
 | 116 | Nurix Therapeutics Inc. | | 181.55% | 0.0 | |
 | 117 | Korro Bio Inc. | | 180.77% | -48.0 | |
 | 118 | Deciphera Pharmaceuticals Inc. | | 180.41% | -67.0 | |
 | 119 | MUSTANG BIO INC. | | 180.11% | 55.0 | |
| 120 | Equillium Inc. | | 178.57% | 2.0 | |
 | 121 | OPKO HEALTH INC. | | 178.01% | -25.0 | |
| 122 | TENAX THERAPEUTICS INC. | | 174.64% | -7.0 | |
 | 123 | Aeglea BioTherapeutics Inc. | | 174.04% | 90.0 | |
 | 124 | Cryoport Inc. | | 174.01% | 0.0 | |
 | 125 | Hepion Pharmaceuticals Inc. | | 173.83% | -36.0 | |
 | 126 | GERON CORP | | 173.78% | -39.0 | |
 | 127 | Annovis Bio Inc. | | 172.65% | 0.0 | |
 | 128 | CHIMERIX INC | | 172.10% | 9.0 | |
 | 129 | NATURES SUNSHINE PRODUCTS INC | | 172.07% | -21.0 | |
 | 130 | Spero Therapeutics Inc. | | 170.21% | 30.0 | |
 | 131 | ACADIA PHARMACEUTICALS INC | | 169.84% | -85.0 | |
 | 132 | LEAP THERAPEUTICS INC. | | 168.78% | 212.0 | |
 | 133 | BIO-PATH HOLDINGS INC | | 168.22% | -92.0 | |
| 134 | ALEXION PHARMACEUTICALS INC. | | 167.91% | -56.0 | |
 | 135 | TG THERAPEUTICS INC. | | 167.75% | 158.0 | |
 | 136 | LEXICON PHARMACEUTICALS INC. | | 167.46% | 31.0 | |
 | 137 | Royalty Pharma plc | | 166.05% | 0.0 | |
 | 138 | MACROGENICS INC | | 164.28% | -8.0 | |
 | 139 | Lifevantage Corp | | 162.81% | -13.0 | |
 | 140 | AMARIN CORP PLC\UK | | 162.71% | -55.0 | |
 | 141 | SYNLOGIC INC. | | 160.90% | -75.0 | |
 | 142 | ORAMED PHARMACEUTICALS INC. | | 159.76% | 45.0 | |
 | 143 | Alaunos Therapeutics Inc. | | 157.99% | 0.0 | |
 | 144 | Atea Pharmaceuticals Inc. | | 157.91% | 0.0 | |
 | 145 | Zymeworks BC Inc. | | 157.32% | -3.0 | |
 | 146 | IDEAYA Biosciences Inc. | | 153.92% | 0.0 | |
 | 147 | Adicet Bio Inc. | | 153.89% | 0.0 | |
 | 148 | Checkpoint Therapeutics Inc. | | 151.65% | 67.0 | |
 | 149 | Edesa Biotech Inc. | | 150.27% | 0.0 | |
| 150 | Citius Pharmaceuticals Inc. | | 149.84% | 0.0 | |
| 151 | Sierra Oncology Inc. | | 149.70% | 0.0 | |
| 152 | Aprea Therapeutics Inc. | | 148.57% | -126.0 | |
 | 153 | G1 Therapeutics Inc. | | 147.12% | -91.0 | |
 | 154 | Benitec Biopharma Inc. | | 143.64% | 0.0 | |
 | 155 | Xenetic Biosciences Inc. | | 143.07% | -28.0 | |
 | 156 | AYTU BIOPHARMA INC | | 142.23% | 120.0 | |
 | 157 | Arcus Biosciences Inc. | | 142.21% | -60.0 | |
 | 158 | NEKTAR THERAPEUTICS | | 140.77% | -52.0 | |
 | 159 | uniQure N.V. | | 138.61% | -48.0 | |
 | 160 | Cyclerion Therapeutics Inc. | | 138.27% | -62.0 | |
 | 161 | BeiGene Ltd. | | 138.13% | 35.0 | |
 | 162 | OPIANT PHARMACEUTICALS INC. | | 138.04% | -150.0 | |
 | 163 | Verastem Inc. | | 135.00% | 140.0 | |
 | 164 | Summit Therapeutics Inc. | | 134.53% | 0.0 | |
| 165 | Bellerophon Therapeutics Inc. | | 131.97% | 119.0 | |
 | 166 | GYRE THERAPEUTICS INC. | | 131.28% | -5.0 | |
 | 167 | Emergent BioSolutions Inc. | | 129.01% | -21.0 | |
 | 168 | Aditxt Inc. | | 128.98% | 0.0 | |
 | 169 | Homology Medicines Inc. | | 125.70% | -96.0 | |
 | 170 | Pacira BioSciences Inc. | | 125.58% | -1.0 | |
 | 171 | AVADEL PHARMACEUTICALS PLC | | 124.51% | 106.0 | |
 | 172 | SUPERNUS PHARMACEUTICALS INC. | | 124.50% | -48.0 | |
 | 173 | Mirum Pharmaceuticals Inc. | | 124.48% | -119.0 | |
 | 174 | Organogenesis Holdings Inc. | | 121.57% | 49.0 | |
 | 175 | Morphic Holding Inc. | | 120.57% | -32.0 | |
 | 176 | RIGEL PHARMACEUTICALS INC | | 119.34% | 3.0 | |
 | 177 | Aravive Inc. | | 119.30% | -124.0 | |
 | 178 | LIGAND PHARMACEUTICALS INC | | 119.10% | -92.0 | |
 | 179 | Regulus Therapeutics Inc. | | 118.07% | 30.0 | |
 | 180 | Sonoma Pharmaceuticals Inc. | | 117.81% | 14.0 | |
 | 181 | Zynerba Pharmaceuticals Inc. | | 116.82% | -110.0 | |
 | 182 | EXICURE INC. | | 116.48% | -70.0 | |
 | 183 | Calithera Biosciences Inc. | | 115.48% | -81.0 | |
 | 184 | F-star Therapeutics Inc. | | 115.43% | 0.0 | |
 | 185 | BIODELIVERY SCIENCES INTERNATIONAL INC | | 114.05% | 4.0 | |
 | 186 | Fulcrum Therapeutics Inc. | | 113.30% | -30.0 | |
 | 187 | PERRIGO Co plc | | 111.91% | -53.0 | |
 | 188 | NovaBay Pharmaceuticals Inc. | | 111.77% | 106.0 | |
 | 189 | Entasis Therapeutics Holdings Inc. | | 111.37% | -27.0 | |
 | 190 | Ayala Pharmaceuticals Inc. | | 108.55% | -127.0 | |
 | 191 | Guardion Health Sciences Inc. | | 108.41% | -81.0 | |
 | 192 | Theravance Biopharma Inc. | | 106.70% | -41.0 | |
 | 193 | Elanco Animal Health Inc | | 105.96% | -86.0 | |
 | 194 | GALECTIN THERAPEUTICS INC | | 103.68% | -163.0 | |
 | 195 | Phathom Pharmaceuticals Inc. | | 103.59% | -32.0 | |
 | 196 | Catalent Inc. | | 103.49% | -191.0 | |
 | 197 | Fortress Biotech Inc. | | 102.40% | 38.0 | |
 | 198 | OMEROS CORP | | 101.15% | 5.0 | |
 | 199 | ALBIREO PHARMA INC. | | 100.80% | -19.0 | |
 | 200 | Ampio Pharmaceuticals Inc. | | 100.74% | 60.0 | |
 | 201 | Zosano Pharma Corp | | 100.21% | 86.0 | |
 | 202 | Foghorn Therapeutics Inc. | | 100.08% | 0.0 | |
 | 203 | BICYCLE THERAPEUTICS plc | | 99.06% | -144.0 | |
 | 204 | ATOSSA THERAPEUTICS INC. | | 98.79% | -12.0 | |
 | 205 | Liquidia Corp | | 97.68% | 0.0 | |
 | 206 | PFIZER INC | | 97.00% | -38.0 | |
 | 207 | Viracta Therapeutics Inc. | | 95.50% | -52.0 | |
 | 208 | OTONOMY INC. | | 94.68% | 8.0 | |
 | 209 | Savara Inc | | 93.97% | -68.0 | |
 | 210 | FIBROGEN INC | | 93.73% | 0.0 | |
| 211 | REVIVA PHARMACEUTICALS HOLDINGS INC. | | 93.17% | 0.0 | |
 | 212 | ABEONA THERAPEUTICS INC. | | 92.22% | -124.0 | |
| 213 | ZOGENIX INC. | | 91.41% | 30.0 | |
 | 214 | Global Blood Therapeutics Inc. | | 90.71% | -97.0 | |
 | 215 | VERU INC. | | 89.94% | -77.0 | |
 | 216 | ARDELYX INC. | | 88.51% | -95.0 | |
| 217 | Kadmon Holdings Inc. | | 85.55% | -125.0 | |
 | 218 | ANI PHARMACEUTICALS INC | | 85.53% | -66.0 | |
 | 219 | PROTHENA CORP PUBLIC LTD CO | | 85.22% | -101.0 | |
 | 220 | LIFECORE BIOMEDICAL INC. \DE\ | | 84.02% | -87.0 | |
| 221 | ARTELO BIOSCIENCES INC. | | 83.88% | -151.0 | |
 | 222 | Seres Therapeutics Inc. | | 82.73% | 83.0 | |
 | 223 | ELITE PHARMACEUTICALS INC NV | | 81.96% | 0.0 | |
| 224 | Intec Pharma Ltd. | | 79.74% | 94.0 | |
 | 225 | Y-mAbs Therapeutics Inc. | | 78.87% | -180.0 | |
 | 226 | Viatris Inc | | 78.44% | 0.0 | |
 | 227 | Anixa Biosciences Inc | | 77.48% | 72.0 | |
 | 228 | Pulmatrix Inc. | | 77.04% | 22.0 | |
| 229 | Strongbridge Biopharma plc | | 76.75% | -59.0 | |
 | 230 | HERON THERAPEUTICS INC. DE | | 76.31% | -127.0 | |
 | 231 | Statera Biopharma Inc. | | 75.20% | 82.0 | |
| 232 | Applied Therapeutics Inc. | | 73.85% | -12.0 | |
 | 233 | INTEGRATED BIOPHARMA INC | | 73.04% | -5.0 | |
 | 234 | Avid Bioservices Inc. | | 71.07% | -151.0 | |
 | 235 | ALPINE IMMUNE SCIENCES INC. | | 69.90% | -5.0 | |
 | 236 | Zoetis Inc. | | 69.31% | -36.0 | |
 | 237 | AGILE THERAPEUTICS INC | | 68.17% | -193.0 | |
 | 238 | Revance Therapeutics Inc. | | 67.85% | -81.0 | |
 | 239 | CHINA PHARMA HOLDINGS INC. | | 65.94% | 24.0 | |
 | 240 | Moleculin Biotech Inc. | | 65.55% | -54.0 | |
| 241 | CHIASMA INC | | 63.68% | 0.0 | |
 | 242 | COLLEGIUM PHARMACEUTICAL INC | | 62.95% | -31.0 | |
 | 243 | BELLICUM PHARMACEUTICALS INC | | 57.90% | 65.0 | |
 | 244 | BRISTOL MYERS SQUIBB CO | | 56.25% | 0.0 | |
 | 245 | AGIOS PHARMACEUTICALS INC. | | 55.07% | -113.0 | |
 | 246 | SPECTRUM PHARMACEUTICALS INC | | 54.65% | -118.0 | |
 | 247 | Merus N.V. | | 52.27% | -69.0 | |
 | 248 | Sio Gene Therapies Inc. | | 52.10% | 20.0 | |
 | 249 | MEI Pharma Inc. | | 51.88% | -105.0 | |
 | 250 | AVEO PHARMACEUTICALS INC. | | 50.99% | -66.0 | |
 | 251 | UroGen Pharma Ltd. | | 50.45% | -172.0 | |
 | 252 | IONIS PHARMACEUTICALS INC | | 49.98% | -129.0 | |
 | 253 | LANNETT CO INC | | 49.50% | -31.0 | |
 | 254 | PHIBRO ANIMAL HEALTH CORP | | 48.57% | -63.0 | |
 | 255 | ROCKWELL MEDICAL INC. | | 45.97% | -13.0 | |
 | 256 | KINETA INC. DE | | 45.18% | -84.0 | |
 | 257 | CHEMBIO DIAGNOSTICS INC. | | 43.53% | -60.0 | |
 | 258 | CTI BIOPHARMA CORP | | 42.90% | 3.0 | |
 | 259 | Unity Biotechnology Inc. | | 42.36% | -139.0 | |
 | 260 | Travere Therapeutics Inc. | | 38.47% | -48.0 | |
 | 261 | Imunon Inc. | | 37.23% | -34.0 | |
 | 262 | ELI LILLY & Co | | 37.11% | -44.0 | |
 | 263 | ImmunoGen Inc. | | 35.35% | 34.0 | |
 | 264 | Harmony Biosciences Holdings Inc. | | 34.40% | 0.0 | |
 | 265 | KIORA PHARMACEUTICALS INC | | 33.26% | -67.0 | |
 | 266 | TEVA PHARMACEUTICAL INDUSTRIES LTD | | 33.11% | -58.0 | |
 | 267 | Lipocine Inc. | | 30.67% | -13.0 | |
 | 268 | ALNYLAM PHARMACEUTICALS INC. | | 30.57% | -104.0 | |
 | 269 | AMICUS THERAPEUTICS INC. | | 29.38% | -81.0 | |
 | 270 | Sarepta Therapeutics Inc. | | 29.04% | -60.0 | |
 | 271 | Aclaris Therapeutics Inc. | | 26.42% | 14.0 | |
 | 272 | RVL Pharmaceuticals plc | | 25.26% | -15.0 | |
 | 273 | EYENOVIA INC. | | 24.96% | -21.0 | |
 | 274 | Assertio Holdings Inc. | | 24.44% | 0.0 | |
 | 275 | Aptevo Therapeutics Inc. | | 23.85% | -3.0 | |
| 276 | Dicerna Pharmaceuticals Inc | | 19.44% | -51.0 | |
 | 277 | PIERIS PHARMACEUTICALS INC. | | 18.98% | -73.0 | |
 | 278 | Timber Pharmaceuticals Inc. | | 18.24% | 0.0 | |
 | 279 | Amneal Pharmaceuticals Inc. | | 17.58% | -38.0 | |
 | 280 | CytomX Therapeutics Inc. | | 15.80% | -31.0 | |
 | 281 | MADRIGAL PHARMACEUTICALS INC. | | 15.34% | -260.0 | |
 | 282 | PREDICTIVE TECHNOLOGY GROUP INC. | | 15.20% | -222.0 | |
 | 283 | CYTOKINETICS INC | | 14.14% | -8.0 | |
 | 284 | PLx Pharma Winddown Corp. | | 12.94% | 23.0 | |
 | 285 | Lexaria Bioscience Corp. | | 11.65% | -45.0 | |
 | 286 | DYNAVAX TECHNOLOGIES CORP | | 8.35% | -8.0 | |
 | 287 | Akebia Therapeutics Inc. | | 8.16% | -97.0 | |
 | 288 | Mallinckrodt plc | | 2.95% | 0.0 | |
 | 289 | Wave Life Sciences Ltd. | | 2.60% | -25.0 | |
 | 290 | Bausch Health Companies Inc. | | 1.48% | -46.0 | |
 | 291 | Apellis Pharmaceuticals Inc. | | 0.81% | -1.0 | |
| 292 | AILERON THERAPEUTICS INC | | -2.37% | -41.0 | |
| 293 | Molecular Templates Inc. | | -2.59% | -117.0 | |
 | 294 | Eton Pharmaceuticals Inc. | | -5.57% | -49.0 | |
 | 295 | OCULAR THERAPEUTIX INC | | -11.06% | 15.0 | |
 | 296 | Ovid Therapeutics Inc. | | -11.07% | 0.0 | |
 | 297 | CV Sciences Inc. | | -11.99% | -122.0 | |
 | 298 | Emmaus Life Sciences Inc. | | -12.28% | 0.0 | |
 | 299 | Jaguar Health Inc. | | -12.33% | -46.0 | |
 | 300 | SCYNEXIS INC | | -17.60% | -17.0 | |
| 301 | Theriva Biologics Inc. | | -18.55% | -84.0 | |
 | 302 | Clearside Biomedical Inc. | | -21.00% | -23.0 | |
 | 303 | iBio Inc. | | -21.22% | -30.0 | |
| 304 | XERIS PHARMACEUTICALS INC | | -23.25% | 2.0 | |
 | 305 | HUMANIGEN INC | | -24.59% | 41.0 | |
 | 306 | CEN BIOTECH INC | | -25.96% | 19.0 | |
 | 307 | PUMA BIOTECHNOLOGY INC. | | -28.42% | -49.0 | |
 | 308 | Carisma Therapeutics Inc. | | -30.03% | 4.0 | |
 | 309 | ATHERSYS INC NEW | | -37.07% | 0.0 | |
 | 310 | Karyopharm Therapeutics Inc. | | -37.90% | -39.0 | |
 | 311 | Corbus Pharmaceuticals Holdings Inc. | | -41.93% | 5.0 | |
 | 312 | BridgeBio Pharma Inc. | | -44.88% | -193.0 | |
 | 313 | Societal CDMO Inc. | | -46.85% | -51.0 | |
 | 314 | OptiNose Inc. | | -47.53% | -67.0 | |
 | 315 | vTv Therapeutics Inc. | | -48.70% | 13.0 | |
 | 316 | International Stem Cell CORP | | -52.43% | -49.0 | |
 | 317 | NVN Liquidation Inc. | | -53.31% | 0.0 | |
| 318 | Flexion Therapeutics Inc | | -54.71% | -22.0 | |
 | 319 | ABVC BIOPHARMA INC. | | -55.11% | -39.0 | |
 | 320 | Cartesian Therapeutics Inc. | | -57.25% | 0.0 | |
 | 321 | Histogen Inc. | | -60.87% | -256.0 | |
| 322 | CQENS Technologies Inc. | | -62.02% | -3.0 | |
 | 323 | SOLIGENIX INC. | | -62.39% | -19.0 | |
 | 324 | Avalo Therapeutics Inc. | | -67.53% | -139.0 | |
 | 325 | IntelGenx Technologies Corp. | | -74.98% | -25.0 | |
 | 326 | Esperion Therapeutics Inc. | | -76.97% | -60.0 | |
 | 327 | ONCOSEC MEDICAL Inc | | -80.50% | -132.0 | |
 | 328 | Acer Therapeutics Inc. | | -83.22% | -96.0 | |
 | 329 | INTERCEPT PHARMACEUTICALS INC. | | -84.73% | -60.0 | |
 | 330 | Eterna Therapeutics Inc. | | -89.25% | -129.0 | |
 | 331 | SEELOS THERAPEUTICS INC. | | -90.56% | 16.0 | |
 | 332 | Synaptogenix Inc. | | -92.42% | 0.0 | |
 | 333 | Clovis Oncology Inc. | | -93.73% | -32.0 | |
| 334 | Adamas Pharmaceuticals Inc | | -98.86% | -46.0 | |
| 335 | Rezolute Inc. | | -105.26% | -11.0 | |
| 336 | ADIAL PHARMACEUTICALS INC. | | -115.39% | -163.0 | |
 | 337 | AMERICAN BIO MEDICA CORP | | -115.75% | 0.0 | |
 | 338 | Evolus Inc. | | -117.49% | -109.0 | |
 | 339 | Paratek Pharmaceuticals Inc. | | -119.51% | -47.0 | |
| 340 | Chemomab Therapeutics Ltd. | | -124.28% | -320.0 | |
| 341 | Radius Health Inc. | | -127.02% | 0.0 | |
 | 342 | ACELRX PHARMACEUTICALS INC | | -144.71% | 0.0 | |
 | 343 | Innovation Pharmaceuticals Inc. | | -145.34% | 0.0 | |
 | 344 | DMK PHARMACEUTICALS Corp | | -151.64% | 0.0 | |
 | 345 | MusclePharm Corp | | -153.96% | -23.0 | |
 | 346 | Biohaven Pharmaceutical Holding Co Ltd. | | -156.95% | 0.0 | |
 | 347 | INFINITY PHARMACEUTICALS INC. | | -157.52% | -52.0 | |
 | 348 | Aquestive Therapeutics Inc. | | -159.75% | -46.0 | |
 | 349 | TherapeuticsMD Inc. | | -162.89% | -67.0 | |
 | 350 | Evoke Pharma Inc | | -169.22% | -111.0 | |
| 351 | GT Biopharma Inc. | | -175.96% | 0.0 | |
| 352 | BIORA THERAPEUTICS INC. | | -181.09% | 0.0 | |
 | 353 | MANNKIND CORP | | -184.88% | -33.0 | |
| 354 | REGENEREX PHARMA INC. | | -188.13% | 0.0 | |
 | 355 | Orgenesis Inc. | | -198.30% | -149.0 | |
| 356 | Teligent Inc. | | -217.94% | -100.0 | |
| 357 | NeuroBo Pharmaceuticals Inc. | | -234.68% | -111.0 | |
| 358 | Skye Bioscience Inc. | | -236.49% | -219.0 | |
 | 359 | Iterum Therapeutics plc | | -239.30% | -21.0 | |
 | 360 | ACURA PHARMACEUTICALS INC | | -242.24% | 0.0 | |
| 361 | Regen BioPharma Inc | | -242.75% | 0.0 | |
| 362 | Vicapsys Life Sciences Inc. | | -244.69% | 0.0 | |
 | 363 | CytoDyn Inc. | | -248.62% | -33.0 | |
 | 364 | VYNE Therapeutics Inc. | | -255.90% | -205.0 | |
 | 365 | VACCINEX INC. | | -256.33% | -10.0 | |
| 366 | ENDONOVO THERAPEUTICS INC. | | -256.47% | -26.0 | |
| 367 | First Wave BioPharma Inc. | | -261.79% | -58.0 | |
| 368 | Urovant Sciences Ltd. | | -266.99% | -144.0 | |
| 369 | CANNAPHARMARX INC. | | -268.25% | -71.0 | |
| 370 | ZEVRA THERAPEUTICS INC. | | -285.91% | -36.0 | |
| 371 | SANGUI BIOTECH INTERNATIONAL INC | | -293.06% | -36.0 | |
 | 372 | AgeX Therapeutics Inc. | | -305.30% | 0.0 | |
| 373 | Kintara Therapeutics Inc. | | -309.04% | 0.0 | |
 | 374 | Innovation1 Biotech Inc. | | -311.65% | 0.0 | |
| 375 | REGENERX BIOPHARMACEUTICALS INC | | -324.92% | -44.0 | |
| 376 | CARDAX INC. | | -346.34% | -43.0 | |
 | 377 | Vistagen Therapeutics Inc. | | -354.62% | -66.0 | |
 | 378 | Biostax Corp. | | -358.58% | -37.0 | |
| 379 | PROVECTUS BIOPHARMACEUTICALS INC. | | -373.67% | 0.0 | |
 | 380 | Kaya Holdings Inc. | | -373.73% | 0.0 | |
| 381 | America Great Health | | -378.58% | 0.0 | |
| 382 | GlobeStar Therapeutics Corp | | -399.40% | -43.0 | |
| 383 | Cell Source Inc. | | -411.87% | 0.0 | |
| 384 | Rebus Holdings Inc. | | -417.70% | -48.0 | |
| 385 | BIOVIE INC. | | -418.09% | -202.0 | |
 | 386 | Ainos Inc. | | -425.72% | -57.0 | |
| 387 | RespireRx Pharmaceuticals Inc. | | -441.37% | -45.0 | |
| 388 | Greater Cannabis Company Inc. | | -447.61% | -39.0 | |
| 389 | BIOXYTRAN INC | | -448.69% | -39.0 | |
| 390 | BIOADAPTIVES INC. | | -454.47% | 0.0 | |
| 391 | Earth Science Tech Inc. | | -461.80% | -43.0 | |
| 392 | Scopus BioPharma Inc. | | -485.50% | 0.0 | |
| 393 | Wellness Center USA Inc. | | -499.73% | -39.0 | |
 | 394 | One World Products Inc. | | -536.35% | -38.0 | |
| 395 | NORTHWEST BIOTHERAPEUTICS INC | | -538.82% | -63.0 | |
 | 396 | CNBX Pharmaceuticals Inc. | | -540.35% | -392.0 | |
| 397 | Propanc Biopharma Inc. | | -568.13% | -45.0 | |
| 398 | HST Global Inc. | | -612.92% | 0.0 | |
 | 399 | Nascent Biotech Inc. | | -621.09% | 0.0 | |
| 400 | ACTAVIA LIFE SCIENCES INC. | | -725.92% | -234.0 | |
| 401 | Q BioMed Inc. | | -1321.19% | -48.0 | |
| 402 | ProtoKinetix Inc. | | -2689.86% | -45.0 | |
