2021 US Pharma

1. CATALYST PHARMACEUTICALS INC.

456.54%

2. SIGA TECHNOLOGIES INC

437.42%

3. Sage Therapeutics Inc.

421.92%

4. CEN BIOTECH INC

414.35%

5. CORCEPT THERAPEUTICS INC

324.58%

6. Blueprint Medicines Corp

293.49%

7. VERTEX PHARMACEUTICALS INC MA

275.77%

8. REGENERON PHARMACEUTICALS INC.

226.67%

9. Jazz Pharmaceuticals plc

211.97%

10. Minerva Neurosciences Inc.

210.29%

11. BIOMARIN PHARMACEUTICAL INC

208.98%

12. UNITED THERAPEUTICS Corp

199.66%

13. ABBOTT LABORATORIES

198.87%

14. Lifevantage Corp

197.95%

15. China Health Industries Holdings Inc.

196.78%

16. Vanda Pharmaceuticals Inc.

193.38%

17. XBiotech Inc.

189.90%

18. Endo International plc

181.80%

19. XOMA Corp

181.61%

20. AbbVie Inc.

171.65%

21. Merck & Co. Inc.

165.69%

22. PROCYON CORP

162.86%

23. ANAPTYSBIO INC

162.61%

24. DURECT CORP

159.98%

25. EAGLE PHARMACEUTICALS INC.

158.12%

26. NATURES SUNSHINE PRODUCTS INC

157.27%

27. CASSAVA SCIENCES INC

157.06%

28. Greenwich LifeSciences Inc.

153.63%

29. Regen BioPharma Inc

152.85%

30. LUMOS PHARMA INC.

148.75%

31. Royalty Pharma plc

148.38%

32. Enochian Biosciences Inc

143.79%

33. ENANTA PHARMACEUTICALS INC

137.69%

34. PMV Pharmaceuticals Inc.

137.23%

35. GT Biopharma Inc.

135.35%

36. Pacira BioSciences Inc.

131.91%

37. ALX ONCOLOGY HOLDINGS INC

129.84%

38. Emergent BioSolutions Inc.

129.61%

39. Aadi Bioscience Inc.

127.56%

40. ALEXION PHARMACEUTICALS INC.

123.39%

41. Amphastar Pharmaceuticals Inc.

123.04%

42. OPKO HEALTH INC.

122.10%

43. BIODELIVERY SCIENCES INTERNATIONAL INC

120.28%

44. SUPERNUS PHARMACEUTICALS INC.

118.23%

45. INTEGRATED BIOPHARMA INC

117.29%

46. TENAX THERAPEUTICS INC.

111.71%

47. Corvus Pharmaceuticals Inc.

111.16%

48. NextCure Inc.

110.19%

49. GW PHARMACEUTICALS PLC

107.18%

50. MARIZYME INC

106.73%

51. Organogenesis Holdings Inc.

105.47%

52. Turning Point Therapeutics Inc.

100.74%

53. Shattuck Labs Inc.

98.94%

54. Atea Pharmaceuticals Inc.

94.64%

55. AMARIN CORP PLCUK

94.62%

56. PLIANT THERAPEUTICS INC.

92.65%

57. Zoetis Inc.

92.03%

58. AVADEL PHARMACEUTICALS PLC

91.36%

59. Kura Oncology Inc.

89.99%

60. PFIZER INC

88.97%

61. Avidity Biosciences Inc.

86.71%

62. Xencor Inc

82.97%

63. Cryoport Inc.

82.88%

64. Akouos Inc.

81.10%

65. Viking Therapeutics Inc.

80.62%

66. BODY & MIND INC.

80.24%

67. Catalent Inc.

77.79%

68. Keros Therapeutics Inc.

74.85%

69. Dyne Therapeutics Inc.

74.24%

70. OPIANT PHARMACEUTICALS INC.

73.32%

71. ELI LILLY & Co

72.30%

72. PERRIGO Co plc

70.19%

73. LIGAND PHARMACEUTICALS INC

69.25%

74. Xenon Pharmaceuticals Inc.

68.99%

75. ALIMERA SCIENCES INC

68.91%

76. Pandion Therapeutics Inc.

67.63%

77. Stoke Therapeutics Inc.

66.23%

78. Frequency Therapeutics Inc.

61.76%

79. ChemoCentryx Inc.

61.03%

80. MERRIMACK PHARMACEUTICALS INC

60.56%

81. Elanco Animal Health Inc

59.59%

82. Vincerx Pharma Inc.

58.01%

83. Nurix Therapeutics Inc.

57.29%

84. COLLEGIUM PHARMACEUTICAL INC

56.87%

85. ARROWHEAD PHARMACEUTICALS INC.

56.75%

86. ARVINAS INC.

56.26%

87. MEDICINOVA INC

55.89%

88. Kronos Bio Inc.

54.79%

89. Karuna Therapeutics Inc.

53.08%

90. Arcturus Therapeutics Holdings Inc.

51.51%

91. Viatris Inc

48.80%

92. AYTU BIOPHARMA INC

46.73%

93. Repare Therapeutics Inc.

46.16%

94. Trillium Therapeutics Inc.

40.76%

95. IDEAYA Biosciences Inc.

39.14%

96. Altimmune Inc.

37.29%

97. PHIBRO ANIMAL HEALTH CORP

36.74%

98. NightHawk Biosciences Inc.

30.54%

99. ANI PHARMACEUTICALS INC

30.38%

100. LANDEC CORP CA

21.90%

101. Protagonist Therapeutics Inc

21.39%

102. 89bio Inc.

20.32%

103. LANNETT CO INC

20.07%

104. Amneal Pharmaceuticals Inc.

16.53%

105. CHINOOK THERAPEUTICS INC.

14.04%

106. ELITE PHARMACEUTICALS INC NV

13.38%

107. Aurinia Pharmaceuticals Inc.

12.18%

108. Arcus Biosciences Inc.

10.30%

109. ASSEMBLY BIOSCIENCES INC.

7.46%

110. Mirati Therapeutics Inc.

5.45%

111. BRISTOL MYERS SQUIBB CO

4.48%

112. VBI Vaccines Inc BC

4.27%

113. Avid Bioservices Inc.

4.15%

114. Prelude Therapeutics Inc

1.93%

115. Emmaus Life Sciences Inc.

1.57%

116. FIVE PRIME THERAPEUTICS INC.

-1.23%

117. Cellectar Biosciences Inc.

-3.23%

118. ROCKET PHARMACEUTICALS INC.

-3.96%

119. Bausch Health Companies Inc.

-5.51%

120. TREVENA INC

-6.60%

121. CHINA PHARMA HOLDINGS INC.

-7.44%

122. TEVA PHARMACEUTICAL INDUSTRIES LTD

-9.82%

123. Nkarta Inc.

-9.93%

124. Syndax Pharmaceuticals Inc

-11.24%

125. Harmony Biosciences Holdings Inc.

-11.39%

126. Morphic Holding Inc.

-13.61%

127. Assertio Holdings Inc.

-19.31%

128. ESSA Pharma Inc.

-19.58%

129. Lantern Pharma Inc.

-22.06%

130. Kindred Biosciences Inc.

-22.98%

131. Sonoma Pharmaceuticals Inc.

-23.37%

132. CytomX Therapeutics Inc.

-23.65%

133. ImmunoGen Inc.

-26.31%

134. GeoVax Labs Inc.

-26.46%

135. Adicet Bio Inc.

-28.41%

136. Cogent Biosciences Inc.

-34.13%

137. ORAMED PHARMACEUTICALS INC.

-37.48%

138. Salarius Pharmaceuticals Inc.

-39.52%

139. ALPINE IMMUNE SCIENCES INC.

-39.80%

140. BELLICUM PHARMACEUTICALS INC

-43.53%

141. GERON CORP

-45.43%

142. EXICURE INC.

-46.31%

143. Dicerna Pharmaceuticals Inc

-47.92%

144. FIBROGEN INC

-47.94%

145. IONIS PHARMACEUTICALS INC

-49.18%

146. Intra-Cellular Therapies Inc.

-51.01%

147. KalVista Pharmaceuticals Inc.

-51.32%

148. LEXICON PHARMACEUTICALS INC.

-52.53%

149. Matinas BioPharma Holdings Inc.

-52.59%

150. Mallinckrodt plc

-53.16%

151. Sarepta Therapeutics Inc.

-54.22%

152. Aptinyx Inc.

-55.01%

153. MusclePharm Corp

-55.25%

154. Atreca Inc.

-55.79%

155. RIGEL PHARMACEUTICALS INC

-56.55%

156. Zentalis Pharmaceuticals Inc.

-56.86%

157. NGM BIOPHARMACEUTICALS INC

-57.19%

158. Verona Pharma plc

-58.92%

159. MEI Pharma Inc.

-59.07%

160. BeiGene Ltd.

-60.13%

161. CymaBay Therapeutics Inc.

-60.84%

162. Inozyme Pharma Inc.

-61.09%

163. NEKTAR THERAPEUTICS

-62.19%

164. Actinium Pharmaceuticals Inc.

-63.64%

165. ARENA PHARMACEUTICALS INC

-63.83%

166. Foghorn Therapeutics Inc.

-64.95%

167. Seres Therapeutics Inc.

-66.41%

168. Mersana Therapeutics Inc.

-66.91%

169. RVL Pharmaceuticals plc

-67.86%

170. DYNAVAX TECHNOLOGIES CORP

-72.71%

171. Metacrine Inc.

-76.30%

172. Sesen Bio Inc.

-79.32%

173. ALNYLAM PHARMACEUTICALS INC.

-82.14%

174. CYTOKINETICS INC

-82.40%

175. Zymeworks Inc.

-84.62%

176. GLYCOMIMETICS INC

-86.49%

177. MACROGENICS INC

-87.22%

178. Fortress Biotech Inc.

-87.45%

179. Equillium Inc.

-88.80%

180. BioXcel Therapeutics Inc.

-91.12%

181. Travere Therapeutics Inc.

-91.44%

182. Monopar Therapeutics

-92.31%

183. BICYCLE THERAPEUTICS plc

-92.98%

184. uniQure N.V.

-94.13%

185. ZOGENIX INC.

-95.30%

186. ACADIA PHARMACEUTICALS INC

-96.79%

187. PUMA BIOTECHNOLOGY INC.

-101.24%

188. PROTHENA CORP PUBLIC LTD CO

-103.26%

189. Global Blood Therapeutics Inc.

-106.26%

190. AMICUS THERAPEUTICS INC.

-107.36%

191. IVERIC bio Inc.

-109.56%

192. Syros Pharmaceuticals Inc.

-111.31%

193. Immunome Inc.

-112.94%

194. Societal CDMO Inc.

-115.12%

195. Aptevo Therapeutics Inc.

-118.92%

196. VERU INC.

-120.34%

197. Merus N.V.

-121.89%

198. Larimar Therapeutics Inc.

-123.35%

199. Strongbridge Biopharma plc

-125.54%

200. PIERIS PHARMACEUTICALS INC.

-126.90%

201. Citius Pharmaceuticals Inc.

-126.98%

202. Deciphera Pharmaceuticals Inc.

-130.63%

203. SYNLOGIC INC.

-131.90%

204. F-star Therapeutics Inc.

-132.00%

205. Hepion Pharmaceuticals Inc.

-134.10%

206. AGIOS PHARMACEUTICALS INC.

-136.23%

207. Apellis Pharmaceuticals Inc.

-136.91%

208. ALBIREO PHARMA INC.

-137.55%

209. Revance Therapeutics Inc.

-137.61%

210. DiaMedica Therapeutics Inc.

-141.16%

211. Regulus Therapeutics Inc.

-143.29%

212. CHEMBIO DIAGNOSTICS INC.

-143.65%

213. ROCKWELL MEDICAL INC.

-144.76%

214. ATOSSA THERAPEUTICS INC.

-145.26%

215. Mirum Pharmaceuticals Inc.

-148.61%

216. G1 Therapeutics Inc.

-148.62%

217. OTONOMY INC.

-148.68%

218. RAPT Therapeutics Inc.

-150.34%

219. Verastem Inc.

-153.12%

220. TG THERAPEUTICS INC.

-153.84%

221. IMARA Inc.

-154.45%

222. iBio Inc.

-154.54%

223. REVIVA PHARMACEUTICALS HOLDINGS INC.

-155.04%

224. Arcutis Biotherapeutics Inc.

-155.36%

225. CHIASMA INC

-155.40%

226. Phathom Pharmaceuticals Inc.

-156.75%

227. Kiniksa Pharmaceuticals Ltd.

-161.35%

228. Magenta Therapeutics Inc.

-162.83%

229. Aravive Inc.

-162.87%

230. Applied Molecular Transport Inc.

-168.64%

231. Esperion Therapeutics Inc.

-171.58%

232. TFF Pharmaceuticals Inc.

-171.62%

233. SELECTA BIOSCIENCES INC

-171.71%

234. Zosano Pharma Corp

-172.45%

235. ARDELYX INC.

-176.34%

236. ENDONOVO THERAPEUTICS INC.

-177.84%

237. AMERICAN BIO MEDICA CORP

-180.63%

238. Flexion Therapeutics Inc

-184.48%

239. Homology Medicines Inc.

-185.40%

240. Bellerophon Therapeutics Inc.

-187.44%

241. Aeglea BioTherapeutics Inc.

-190.50%

242. RELMADA THERAPEUTICS INC.

-191.53%

243. NeuBase Therapeutics Inc.

-192.36%

244. INTERCEPT PHARMACEUTICALS INC.

-196.15%

245. Savara Inc

-196.28%

246. REGENEREX PHARMA INC.

-197.30%

247. Spero Therapeutics Inc.

-197.44%

248. YUMANITY THERAPEUTICS INC.

-197.82%

249. Summit Therapeutics Inc.

-198.47%

250. Adamas Pharmaceuticals Inc

-198.64%

251. LEAP THERAPEUTICS INC.

-198.81%

252. Pulmatrix Inc.

-199.02%

253. Tonix Pharmaceuticals Holding Corp.

-199.60%

254. CHIMERIX INC

-199.97%

255. International Stem Cell CORP

-209.22%

256. AVEO PHARMACEUTICALS INC.

-214.45%

257. OptiNose Inc.

-214.51%

258. MANNKIND CORP

-216.73%

259. Wave Life Sciences Ltd.

-217.46%

260. KIORA PHARMACEUTICALS INC

-218.21%

261. SCYNEXIS INC

-218.32%

262. Checkpoint Therapeutics Inc.

-219.99%

263. Paratek Pharmaceuticals Inc.

-221.33%

264. Fulcrum Therapeutics Inc.

-223.00%

265. MUSTANG BIO INC.

-223.10%

266. Alaunos Therapeutics Inc.

-223.25%

267. Radius Health Inc.

-228.63%

268. ABEONA THERAPEUTICS INC.

-229.38%

269. XERIS PHARMACEUTICALS INC

-233.99%

270. PLx Pharma Inc.

-234.95%

271. NANOVIRICIDES INC.

-235.20%

272. Celsion CORP

-236.83%

273. Aprea Therapeutics Inc.

-238.32%

274. ACELRX PHARMACEUTICALS INC

-239.21%

275. EYENOVIA INC.

-241.60%

276. ACURA PHARMACEUTICALS INC

-243.18%

277. Genprex Inc.

-244.14%

278. Clovis Oncology Inc.

-244.18%

279. OCULAR THERAPEUTIX INC

-244.92%

280. Akebia Therapeutics Inc.

-246.85%

281. Innovation1 Biotech Inc.

-247.24%

282. Moleculin Biotech Inc.

-252.38%

283. Unity Biotechnology Inc.

-252.45%

284. Theravance Biopharma Inc.

-252.74%

285. Edesa Biotech Inc.

-253.02%

286. CATALYST BIOSCIENCES INC.

-254.74%

287. Novan Inc.

-255.08%

288. IntelGenx Technologies Corp.

-256.05%

289. Liquidia Corp

-256.99%

290. Karyopharm Therapeutics Inc.

-257.19%

291. BridgeBio Pharma Inc.

-279.92%

292. KEMPHARM INC

-281.12%

293. Immune Therapeutics Inc.

-281.25%

294. HERON THERAPEUTICS INC. DE

-281.44%

295. LIXTE BIOTECHNOLOGY HOLDINGS INC.

-284.38%

296. GENEREX BIOTECHNOLOGY CORP

-299.35%

297. Evolus Inc.

-302.22%

298. Intec Pharma Ltd.

-303.56%

299. Kadmon Holdings Inc.

-304.61%

300. BIO-PATH HOLDINGS INC

-308.77%

301. CV Sciences Inc.

-312.32%

302. Cyclerion Therapeutics Inc.

-313.79%

303. SANGUI BIOTECH INTERNATIONAL INC

-313.98%

304. Advaxis Inc.

-316.89%

305. Aclaris Therapeutics Inc.

-319.03%

306. Annovis Bio Inc.

-319.18%

307. Ampio Pharmaceuticals Inc.

-320.54%

308. Aquestive Therapeutics Inc.

-321.15%

309. AGILE THERAPEUTICS INC

-322.86%

310. Molecular Templates Inc.

-327.28%

311. Aditxt Inc.

-329.79%

312. Zynerba Pharmaceuticals Inc.

-330.15%

313. Calithera Biosciences Inc.

-340.62%

314. NovaBay Pharmaceuticals Inc.

-344.41%

315. Jaguar Health Inc.

-345.61%

316. Benitec Biopharma Inc.

-348.04%

317. TherapeuticsMD Inc.

-361.85%

318. Sio Gene Therapies Inc.

-364.25%

319. OMEROS CORP

-368.99%

320. vTv Therapeutics Inc.

-370.79%

321. INFINITY PHARMACEUTICALS INC.

-373.35%

322. SOLIGENIX INC.

-375.45%

323. ABVC BIOPHARMA INC.

-376.17%

324. Sierra Oncology Inc.

-377.23%

325. PROVECTUS BIOPHARMACEUTICALS INC.

-384.64%

326. Lipocine Inc.

-385.94%

327. SPECTRUM PHARMACEUTICALS INC

-387.17%

328. GALECTIN THERAPEUTICS INC

-392.24%

329. America Great Health

-401.52%

330. Biohaven Pharmaceutical Holding Co Ltd.

-408.13%

331. Entasis Therapeutics Holdings Inc.

-416.50%

332. Clearside Biomedical Inc.

-430.33%

333. Teligent Inc.

-431.21%

334. BIORA THERAPEUTICS INC.

-432.51%

335. Xenetic Biosciences Inc.

-435.40%

336. NUGENEREX IMMUNO-ONCOLOGY INC.

-440.85%

337. CTI BIOPHARMA CORP

-441.88%

338. Guardion Health Sciences Inc.

-453.92%

339. Applied Therapeutics Inc.

-458.91%

340. Iterum Therapeutics plc

-459.36%

341. SEELOS THERAPEUTICS INC.

-461.01%

342. Y-mAbs Therapeutics Inc.

-466.65%

343. REGENERX BIOPHARMACEUTICALS INC

-473.13%

344. CARDAX INC.

-486.55%

345. Viracta Therapeutics Inc.

-495.60%

346. Corbus Pharmaceuticals Holdings Inc.

-504.60%

347. PREDICTIVE TECHNOLOGY GROUP INC.

-511.39%

348. Brooklyn ImmunoTherapeutics Inc.

-513.19%

349. Evoke Pharma Inc

-515.73%

350. Ovid Therapeutics Inc.

-519.34%

351. Eton Pharmaceuticals Inc.

-521.05%

352. Kaya Holdings Inc.

-523.95%

353. UroGen Pharma Ltd.

-563.02%

354. Vicapsys Life Sciences Inc.

-573.17%

355. Rebus Holdings Inc.

-590.65%

356. ARTELO BIOSCIENCES INC.

-593.86%

357. Statera Biopharma Inc.

-598.01%

358. Histogen Inc.

-599.07%

359. Anixa Biosciences Inc

-599.24%

360. Synthetic Biologics Inc.

-610.40%

361. Cell Source Inc.

-615.82%

362. RespireRx Pharmaceuticals Inc.

-639.65%

363. ATHERSYS INC NEW

-673.71%

364. ONCOSEC MEDICAL Inc

-682.13%

365. Adamis Pharmaceuticals Corp

-686.30%

366. HUMANIGEN INC

-688.37%

367. Innovation Pharmaceuticals Inc.

-691.06%

368. CANNAPHARMARX INC.

-695.28%

369. GlobeStar Therapeutics Corp

-697.12%

370. BIOADAPTIVES INC.

-699.83%

371. AILERON THERAPEUTICS INC

-706.99%

372. BIOVIE INC.

-711.87%

373. Urovant Sciences Ltd.

-714.23%

374. Avalo Therapeutics Inc.

-733.26%

375. Timber Pharmaceuticals Inc.

-741.12%

376. AgeX Therapeutics Inc.

-760.20%

377. MADRIGAL PHARMACEUTICALS INC.

-783.07%

378. Acer Therapeutics Inc.

-798.63%

379. Lexaria Bioscience Corp.

-872.85%

380. VACCINEX INC.

-922.57%

381. BIOXYTRAN INC

-941.13%

382. First Wave BioPharma Inc.

-953.82%

383. CytoDyn Inc.

-981.19%

384. Chemomab Therapeutics Ltd.

-983.89%

385. CQENS Technologies Inc.

-993.92%

386. Wellness Center USA Inc.

994.56%

387. Ainos Inc.

-1002.55%

388. Earth Science Tech Inc.

-1018.83%

389. Rezolute Inc.

-1022.32%

390. VistaGen Therapeutics Inc.

-1049.49%

391. Skye Bioscience Inc.

-1068.56%

392. Synaptogenix Inc.

-1098.17%

393. ADIAL PHARMACEUTICALS INC.

-1138.83%

394. Propanc Biopharma Inc.

-1190.35%

395. NORTHWEST BIOTHERAPEUTICS INC

-1191.54%

396. Greater Cannabis Company Inc.

-1302.92%

397. Kintara Therapeutics Inc.

-1309.86%

398. HST Global Inc.

-1321.91%

399. VYNE Therapeutics Inc.

-1333.06%

400. Nascent Biotech Inc.

-1347.62%

401. Orgenesis Inc.

-1409.58%

402. NeuroBo Pharmaceuticals Inc.

-1528.07%

403. Scopus BioPharma Inc.

-1598.29%

404. Rasna Therapeutics Inc.

-1798.87%

405. One World Products Inc.

-2015.09%

406. CNBX Pharmaceuticals Inc.

-2970.22%

407. Q BioMed Inc.

-4819.16%

408. ProtoKinetix Inc.

-11891.70%

409. NEXIEN BIOPHARMA INC.

-41795.90%