2018 US Pharma

1. MERRIMACK PHARMACEUTICALS INC

2919.74%

2. CORCEPT THERAPEUTICS INC

587.07%

3. CONCERT PHARMACEUTICALS INC.

532.39%

4. Sonoma Pharmaceuticals Inc.

415.28%

5. OPIANT PHARMACEUTICALS INC.

364.38%

6. BIOSPECIFICS TECHNOLOGIES CORP

327.05%

7. IVERIC bio Inc.

323.18%

8. EAGLE PHARMACEUTICALS INC.

287.32%

9. SPRING PHARMACEUTICAL GROUP INC.

284.62%

10. Jazz Pharmaceuticals plc

282.47%

11. Avalo Therapeutics Inc.

270.04%

12. ENANTA PHARMACEUTICALS INC

229.51%

13. CAMBREX CORP

226.98%

14. UNITED THERAPEUTICS Corp

221.24%

15. MEI Pharma Inc.

220.45%

16. XYNOMIC PHARMACEUTICALS HOLDINGS INC.

218.90%

17. Emergent BioSolutions Inc.

218.26%

18. Bioverativ Inc.

207.56%

19. REGENERON PHARMACEUTICALS INC.

204.70%

20. Catalent Inc.

189.26%

21. AbbVie Inc.

184.90%

22. ABBOTT LABORATORIES

183.52%

23. SUPERNUS PHARMACEUTICALS INC.

180.78%

24. TENAX THERAPEUTICS INC.

179.18%

25. AVADEL PHARMACEUTICALS PLC

176.70%

26. China Health Industries Holdings Inc.

171.56%

27. Cocrystal Pharma Inc.

165.08%

28. Merck & Co. Inc.

162.64%

29. PROCYON CORP

161.82%

30. XOMA Corp

156.09%

31. Aptevo Therapeutics Inc.

155.82%

32. Amphastar Pharmaceuticals Inc.

137.98%

33. SEELOS THERAPEUTICS INC.

135.19%

34. ANAPTYSBIO INC

130.35%

35. ALEXION PHARMACEUTICALS INC.

124.66%

36. PFIZER INC

124.23%

37. LANDEC CORP CA

120.65%

38. ALPINE IMMUNE SCIENCES INC.

120.38%

39. VERTEX PHARMACEUTICALS INC MA

114.90%

40. MACROGENICS INC

111.24%

41. LIGAND PHARMACEUTICALS INC

110.67%

42. ChemoCentryx Inc.

106.59%

43. JUNIPER PHARMACEUTICALS INC

101.57%

44. RELIV INTERNATIONAL INC

95.02%

45. PERRIGO Co plc

93.09%

46. Allergan plc

86.57%

47. VERU INC.

85.12%

48. ABEONA THERAPEUTICS INC.

81.30%

49. PHIBRO ANIMAL HEALTH CORP

80.59%

50. CELGENE CORP DE

80.07%

51. BIOMARIN PHARMACEUTICAL INC

78.72%

52. DURECT CORP

75.47%

53. Zoetis Inc.

73.54%

54. Sarepta Therapeutics Inc.

72.46%

55. BRISTOL MYERS SQUIBB CO

63.31%

56. CUMBERLAND PHARMACEUTICALS INC

61.42%

57. JOHNSON & JOHNSON

58.88%

58. Lifevantage Corp

58.79%

59. Vanda Pharmaceuticals Inc.

58.07%

60. ANI PHARMACEUTICALS INC

57.85%

61. NATURES SUNSHINE PRODUCTS INC

57.56%

62. Assertio Therapeutics Inc

57.03%

63. AKORN INC

55.62%

64. BeiGene Ltd.

53.27%

65. OPKO HEALTH INC.

53.21%

66. MyoKardia Inc.

48.74%

67. Bausch Health Companies Inc.

48.46%

68. LANNETT CO INC

46.50%

69. Xencor Inc

44.51%

70. Calithera Biosciences Inc.

44.20%

71. Intra-Cellular Therapies Inc.

41.73%

72. IONIS PHARMACEUTICALS INC

36.91%

73. Blueprint Medicines Corp

36.45%

74. Endo International plc

34.41%

75. CATALYST PHARMACEUTICALS INC.

31.86%

76. ELI LILLY & Co

31.57%

77. Health-Right Discoveries Inc.

26.36%

78. Travere Therapeutics Inc.

21.10%

79. SPECTRUM PHARMACEUTICALS INC

16.58%

80. INTEGRATED BIOPHARMA INC

16.54%

81. Brooklyn ImmunoTherapeutics Inc.

14.23%

82. Minerva Neurosciences Inc.

14.23%

83. Savara Inc

13.41%

84. Xenetic Biosciences Inc.

9.45%

85. ACHILLION PHARMACEUTICALS INC

5.60%

86. GERON CORP

0.90%

87. ALNYLAM PHARMACEUTICALS INC.

-4.67%

88. GLYCOMIMETICS INC

-5.02%

89. VBI Vaccines Inc BC

-7.23%

90. Teligent Inc.

-7.93%

91. MEDICINOVA INC

-11.67%

92. CV Sciences Inc.

-12.83%

93. Protagonist Therapeutics Inc

-16.31%

94. OptiNose Inc.

-17.45%

95. ULURU Inc.

-20.82%

96. Molecular Templates Inc.

-21.02%

97. Histogen Inc.

-21.07%

98. Aclaris Therapeutics Inc.

-23.20%

99. CytomX Therapeutics Inc.

-27.08%

100. CymaBay Therapeutics Inc.

-29.99%

101. Loxo Oncology Inc.

-31.89%

102. CHINOOK THERAPEUTICS INC.

-32.01%

103. ZOGENIX INC.

-35.83%

104. CHIMERIX INC

-36.41%

105. ARENA PHARMACEUTICALS INC

-37.09%

106. Apellis Pharmaceuticals Inc.

-40.17%

107. MARINUS PHARMACEUTICALS INC.

-41.40%

108. Enveric Biosciences Inc.

-46.15%

109. VIVUS INC

-49.74%

110. Sonnet BioTherapeutics Holdings Inc.

-58.09%

111. Ainos Inc.

-59.01%

112. Avid Bioservices Inc.

-59.24%

113. PROTHENA CORP PUBLIC LTD CO

-59.52%

114. Akebia Therapeutics Inc.

-59.69%

115. Mersana Therapeutics Inc.

-59.95%

116. NEKTAR THERAPEUTICS

-63.54%

117. IntelGenx Technologies Corp.

-65.88%

118. PIERIS PHARMACEUTICALS INC.

-66.71%

119. ALBIREO PHARMA INC.

-69.83%

120. IMMUNE DESIGN CORP.

-70.44%

121. ORAMED PHARMACEUTICALS INC.

-71.45%

122. Qualigen Therapeutics Inc.

-76.65%

123. ARROWHEAD PHARMACEUTICALS INC.

-79.54%

124. CHINA PHARMA HOLDINGS INC.

-80.40%

125. Pfenex Inc.

-80.65%

126. Orgenesis Inc.

-81.82%

127. Dova Pharmaceuticals Inc.

-82.56%

128. ROCKET PHARMACEUTICALS INC.

-86.19%

129. Flexion Therapeutics Inc

-87.59%

130. ALIMERA SCIENCES INC

-95.21%

131. Arbutus Biopharma Corp

-97.31%

132. Societal CDMO Inc.

-99.88%

133. Kura Oncology Inc.

-100.28%

134. Sesen Bio Inc.

-101.34%

135. ARATANA THERAPEUTICS INC.

-104.19%

136. Old API Wind-down Ltd.

-105.94%

137. Cryoport Inc.

-109.49%

138. LEXICON PHARMACEUTICALS INC.

-113.69%

139. SOPHIRIS BIO INC.

-115.47%

140. NANOVIRICIDES INC.

-115.68%

141. ARTELO BIOSCIENCES INC.

-116.94%

142. PROGENICS PHARMACEUTICALS INC

-120.12%

143. Revance Therapeutics Inc.

-120.14%

144. ARDELYX INC.

-122.30%

145. SYNLOGIC INC.

-123.13%

146. MELINTA THERAPEUTICS INC. NEW

-128.62%

147. uniQure N.V.

-132.09%

148. Citius Pharmaceuticals Inc.

-134.06%

149. Spero Therapeutics Inc.

-134.28%

150. ImmunoGen Inc.

-134.87%

151. DYNAVAX TECHNOLOGIES CORP

-135.50%

152. AILERON THERAPEUTICS INC

-136.38%

153. AKCEA THERAPEUTICS INC.

-139.04%

154. MusclePharm Corp

-142.98%

155. ROCKWELL MEDICAL INC.

-143.93%

156. FIVE PRIME THERAPEUTICS INC.

-146.02%

157. REGENERX BIOPHARMACEUTICALS INC

-147.24%

158. VYNE Therapeutics Inc.

-148.76%

159. Mirati Therapeutics Inc.

-150.04%

160. EXICURE INC.

-150.89%

161. Myovant Sciences Ltd.

-152.15%

162. Neoleukin Therapeutics Inc.

-155.65%

163. Syndax Pharmaceuticals Inc

-155.85%

164. Celsion CORP

-156.54%

165. AMICUS THERAPEUTICS INC.

-157.45%

166. OncoMed Pharmaceuticals Inc

-157.47%

167. Epizyme Inc.

-161.78%

168. Zynerba Pharmaceuticals Inc.

-163.11%

169. SIGA TECHNOLOGIES INC

-164.11%

170. OMEROS CORP

-165.61%

171. CYTOKINETICS INC

-165.74%

172. ARRAY BIOPHARMA INC

-168.89%

173. iBio Inc.

-176.59%

174. Corbus Pharmaceuticals Holdings Inc.

-178.73%

175. AMARIN CORP PLCUK

-178.80%

176. Aeglea BioTherapeutics Inc.

-179.26%

177. Clovis Oncology Inc.

-179.72%

178. MUSTANG BIO INC.

-182.31%

179. Seres Therapeutics Inc.

-186.03%

180. Larimar Therapeutics Inc.

-188.48%

181. Dicerna Pharmaceuticals Inc

-188.48%

182. Adamas Pharmaceuticals Inc

-189.75%

183. Adamis Pharmaceuticals Corp

-190.29%

184. Moleculin Biotech Inc.

-192.04%

185. PORTOLA PHARMACEUTICALS INC

-195.74%

186. Impax Laboratories LLC

-195.87%

187. Jaguar Health Inc.

-200.59%

188. HARROW HEALTH INC.

-202.49%

189. AGIOS PHARMACEUTICALS INC.

203.14%

190. F-star Therapeutics Inc.

-212.16%

191. CNBX Pharmaceuticals Inc.

213.01%

192. XBiotech Inc.

-213.08%

193. Enochian Biosciences Inc

-213.77%

194. PLx Pharma Inc.

-215.63%

195. TherapeuticsMD Inc.

-216.44%

196. Dermira Inc.

-219.47%

197. Fibrocell Science Inc.

-220.05%

198. Paratek Pharmaceuticals Inc.

-221.45%

199. SCYNEXIS INC

-222.49%

200. CATALYST BIOSCIENCES INC.

-222.52%

201. ENDOCYTE INC

-223.64%

202. COLLEGIUM PHARMACEUTICAL INC

-226.83%

203. AVENUE THERAPEUTICS INC.

-227.96%

204. Corium International Inc.

-229.60%

205. AGILE THERAPEUTICS INC

-231.12%

206. BIOVIE INC.

-231.27%

207. Zyla Life Sciences

-231.51%

208. Wave Life Sciences Ltd.

-232.39%

209. Optec International Inc.

-234.02%

210. TESARO Inc.

-236.74%

211. GT Biopharma Inc.

-237.10%

212. CQENS Technologies Inc.

-238.72%

213. Anixa Biosciences Inc

-239.57%

214. G1 Therapeutics Inc.

-241.74%

215. KalVista Pharmaceuticals Inc.

-247.74%

216. CARDAX INC.

-248.90%

217. NightHawk Biosciences Inc.

-248.93%

218. PROTEO INC

-250.93%

219. Neos Therapeutics Inc.

-251.72%

220. Corvus Pharmaceuticals Inc.

-253.41%

221. Processa Pharmaceuticals Inc.

-254.84%

222. SteadyMed Ltd.

-255.86%

223. ARQULE INC

-257.56%

224. Esperion Therapeutics Inc.

-263.80%

225. YUMANITY THERAPEUTICS INC.

-275.98%

226. Achaogen Inc.

-278.31%

227. Aimmune Therapeutics Inc.

-286.16%

228. SELLAS Life Sciences Group Inc.

-289.82%

229. KEMPHARM INC

-294.80%

230. Theravance Biopharma Inc.

-294.86%

231. BELLICUM PHARMACEUTICALS INC

-299.89%

232. Oncternal Therapeutics Inc.

-300.66%

233. Xenon Pharmaceuticals Inc.

-302.38%

234. INTERCEPT PHARMACEUTICALS INC.

-303.49%

235. Edesa Biotech Inc.

-305.57%

236. NovaBay Pharmaceuticals Inc.

-309.76%

237. CTI BIOPHARMA CORP

-313.77%

238. Ra Pharmaceuticals Inc.

-317.77%

239. Syros Pharmaceuticals Inc.

-322.69%

240. Lexaria Bioscience Corp.

-324.40%

241. Karyopharm Therapeutics Inc.

-329.82%

242. INFINITY PHARMACEUTICALS INC.

-330.91%

243. Altimmune Inc.

-333.04%

244. Tempest Therapeutics Inc.

-334.52%

245. OTONOMY INC.

-339.97%

246. SOLIGENIX INC.

-345.32%

247. Verastem Inc.

-347.65%

248. Spotlight Innovation Inc.

-352.38%

249. Guardion Health Sciences Inc.

-355.31%

250. Hepion Pharmaceuticals Inc.

-364.43%

251. Axsome Therapeutics Inc.

-364.46%

252. KIORA PHARMACEUTICALS INC

-365.25%

253. Synthetic Biologics Inc.

-367.79%

254. MANNKIND CORP

-371.24%

255. ACADIA PHARMACEUTICALS INC

-372.21%

256. Sio Gene Therapies Inc.

-372.58%

257. NANOMIX Corp

-376.28%

258. International Stem Cell CORP

-383.57%

259. Nabriva Therapeutics plc

-386.59%

260. Neurotrope Inc.

-387.09%

261. HERON THERAPEUTICS INC. DE

-389.67%

262. Lipocine Inc.

-406.09%

263. Tonix Pharmaceuticals Holding Corp.

-406.29%

264. BIO-PATH HOLDINGS INC

-407.08%

265. KERYX BIOPHARMACEUTICALS INC

-409.36%

266. Adhera Therapeutics Inc.

-415.42%

267. Regulus Therapeutics Inc.

-420.62%

268. CEN BIOTECH INC

-421.43%

269. PEAK PHARMACEUTICALS INC.

-422.75%

270. Ocuphire Pharma Inc.

-423.29%

271. Strongbridge Biopharma plc

-431.23%

272. AVEO PHARMACEUTICALS INC.

-437.61%

273. Viking Therapeutics Inc.

-446.81%

274. AXIM BIOTECHNOLOGIES INC.

-446.83%

275. United Cannabis Corp

-452.58%

276. TREVENA INC

-452.60%

277. Biohaven Pharmaceutical Holding Co Ltd.

-458.85%

278. LEAP THERAPEUTICS INC.

-466.33%

279. Advaxis Inc.

-480.61%

280. Aravive Inc.

-483.35%

281. NORTHWEST BIOTHERAPEUTICS INC

-487.84%

282. EYENOVIA INC.

-491.55%

283. ORAGENICS INC

-502.43%

284. Viracta Therapeutics Inc.

-510.97%

285. ABVC BIOPHARMA INC.

-523.40%

286. Salarius Pharmaceuticals Inc.

-527.32%

287. ALDER BIOPHARMACEUTICALS INC

-529.51%

288. Statera Biopharma Inc.

-530.59%

289. Innovation1 Biotech Inc.

-533.30%

290. OCULAR THERAPEUTIX INC

-539.63%

291. ATOSSA THERAPEUTICS INC.

-539.86%

292. Checkpoint Therapeutics Inc.

-543.63%

293. NEUROPATHIX INC.

-550.72%

294. Kaya Holdings Inc.

-556.43%

295. Matinas BioPharma Holdings Inc.

-562.88%

296. Pulmatrix Inc.

-569.75%

297. Cellectar Biosciences Inc.

-576.88%

298. ENDONOVO THERAPEUTICS INC.

-579.44%

299. Bellerophon Therapeutics Inc.

-591.55%

300. Kintara Therapeutics Inc.

-595.38%

301. NEXUS BIOPHARMA INC

-595.41%

302. Cell Source Inc.

-623.70%

303. CohBar Inc.

-624.13%

304. Emmaus Life Sciences Inc.

-624.63%

305. CASSAVA SCIENCES INC

-630.11%

306. Capstone Therapeutics Corp.

-635.55%

307. TG THERAPEUTICS INC.

-637.58%

308. vTv Therapeutics Inc.

-645.36%

309. Innovation Pharmaceuticals Inc.

-657.12%

310. AYTU BIOPHARMA INC

-669.18%

311. Novan Inc.

-688.60%

312. SANGUI BIOTECH INTERNATIONAL INC

-702.03%

313. LIXTE BIOTECHNOLOGY HOLDINGS INC.

-717.67%

314. Clearside Biomedical Inc.

-724.76%

315. TYME TECHNOLOGIES INC.

-763.33%

316. Ampio Pharmaceuticals Inc.

-766.21%

317. NeuroBo Pharmaceuticals Inc.

-770.42%

318. Immune Therapeutics Inc.

-773.02%

319. ATHERSYS INC NEW

-780.69%

320. Actinium Pharmaceuticals Inc.

-808.26%

321. PUMA BIOTECHNOLOGY INC.

-811.30%

322. Regen BioPharma Inc

-816.32%

323. Astria Therapeutics Inc.

-817.65%

324. HypGen Inc

-860.31%

325. Oncolix Inc.

-902.43%

326. MABVAX THERAPEUTICS HOLDINGS INC.

-923.76%

327. RespireRx Pharmaceuticals Inc.

-936.34%

328. Onconova Therapeutics Inc.

-1053.76%

329. Monopar Therapeutics

-1105.74%

330. ImmunoCellular Therapeutics Ltd.

-1131.13%

331. RELMADA THERAPEUTICS INC.

-1135.24%

332. Rezolute Inc.

-1146.04%

333. VistaGen Therapeutics Inc.

-1203.18%

334. Marker Therapeutics Inc.

-1210.36%

335. Genprex Inc.

-1242.19%

336. CorMedix Inc.

-1278.98%

337. Greater Cannabis Company Inc.

-1287.34%

338. Evofem Biosciences Inc.

-1359.51%

339. Propanc Biopharma Inc.

-1366.58%

340. Skye Bioscience Inc.

-1404.32%

341. GeoVax Labs Inc.

-1408.20%

342. EnzymeBioSystems

-1426.11%

343. Phio Pharmaceuticals Corp.

-1525.66%

344. ProtoKinetix Inc.

-1730.74%

345. Anthera Pharmaceuticals Inc

-1793.52%

346. 9 METERS BIOPHARMA INC.

-2064.67%

347. GlobeStar Therapeutics Corp

-2230.43%

348. Wellness Center USA Inc.

-3087.98%

349. Q BioMed Inc.

-9034.32%