 | 1 | MERRIMACK PHARMACEUTICALS INC |  | 920.82% | 263.0 |  |
 | 2 | CONCERT PHARMACEUTICALS INC. | | 381.87% | 81.0 | |
 | 3 | CORCEPT THERAPEUTICS INC | | 365.88% | 83.0 | |
| 4 | BIOSPECIFICS TECHNOLOGIES CORP | | 354.30% | -3.0 |  |
| 5 | XYNOMIC PHARMACEUTICALS HOLDINGS INC. | | 342.98% | 0.0 |  |
| 6 | SPRING PHARMACEUTICAL GROUP INC. | | 341.36% | -4.0 | |
 | 7 | Jazz Pharmaceuticals plc | | 327.94% | -3.0 | |
 | 8 | Sonoma Pharmaceuticals Inc. | | 312.92% | 137.0 | |
 | 9 | ENANTA PHARMACEUTICALS INC | | 305.19% | -6.0 |  |
 | 10 | ANAPTYSBIO INC | | 298.14% | 0.0 | |
 | 11 | MEI Pharma Inc. | | 297.55% | 0.0 | |
 | 12 | ABEONA THERAPEUTICS INC. | | 283.03% | 16.0 | |
| 13 | TENAX THERAPEUTICS INC. | | 280.30% | 43.0 | |
 | 14 | Intra-Cellular Therapies Inc. | | 279.86% | 35.0 | |
 | 15 | ALPINE IMMUNE SCIENCES INC. | | 279.53% | 54.0 | |
 | 16 | ABBOTT LABORATORIES | | 274.36% | -5.0 | |
 | 17 | EAGLE PHARMACEUTICALS INC. | | 274.19% | -11.0 | |
| 18 | ACHILLION PHARMACEUTICALS INC | | 269.54% | -11.0 | |
 | 19 | CATALYST PHARMACEUTICALS INC. | | 269.11% | 19.0 | |
 | 20 | Emergent BioSolutions Inc. | | 269.06% | 72.0 | |
 | 21 | Catalent Inc. | | 267.14% | -9.0 | |
 | 22 | Blueprint Medicines Corp | | 266.02% | 9.0 | |
| 23 | Cocrystal Pharma Inc. | | 262.89% | 0.0 | |
 | 24 | GERON CORP | | 257.71% | -8.0 | |
 | 25 | MARINUS PHARMACEUTICALS INC. | | 255.24% | 153.0 | |
| 26 | ZOGENIX INC. | | 253.26% | 6.0 | |
 | 27 | GLYCOMIMETICS INC | | 251.13% | 96.0 | |
 | 28 | CHIMERIX INC | | 249.56% | -15.0 | |
 | 29 | PROCYON CORP | | 248.85% | 0.0 | |
 | 30 | China Health Industries Holdings Inc. | | 248.81% | -9.0 | |
 | 31 | VERU INC. | | 246.87% | -22.0 | |
 | 32 | Aclaris Therapeutics Inc. | | 243.69% | -18.0 | |
| 33 | ARTELO BIOSCIENCES INC. | | 232.75% | 245.0 | |
 | 34 | Carisma Therapeutics Inc. | | 230.58% | -29.0 | |
 | 35 | MEDICINOVA INC | | 229.49% | 8.0 | |
 | 36 | ALNYLAM PHARMACEUTICALS INC. | | 229.14% | 69.0 | |
 | 37 | Merck & Co. Inc. | | 228.55% | -15.0 | |
| 38 | MyoKardia Inc. | | 228.31% | 33.0 | |
| 39 | GT Biopharma Inc. | | 225.37% | 207.0 | |
 | 40 | AbbVie Inc. | | 225.03% | -30.0 | |
| 41 | CAMBREX CORP | | 224.57% | 25.0 | |
 | 42 | UNITED THERAPEUTICS Corp | | 223.47% | -34.0 | |
| 43 | IMMUNE DESIGN CORP. | | 222.47% | 45.0 | |
 | 44 | MACROGENICS INC | | 220.75% | -10.0 | |
 | 45 | ALBIREO PHARMA INC. | | 215.71% | 51.0 | |
 | 46 | MUSTANG BIO INC. | | 213.31% | 18.0 | |
 | 47 | XBiotech Inc. | | 212.57% | 67.0 | |
 | 48 | Revance Therapeutics Inc. | | 211.96% | 22.0 | |
| 49 | Molecular Templates Inc. | | 211.26% | 101.0 | |
 | 50 | DYNAVAX TECHNOLOGIES CORP | | 209.60% | 109.0 | |
 | 51 | Qualigen Therapeutics Inc. | | 209.49% | 204.0 | |
 | 52 | Spero Therapeutics Inc. | | 208.31% | 0.0 | |
| 53 | AILERON THERAPEUTICS INC | | 206.99% | 0.0 | |
 | 54 | REGENERON PHARMACEUTICALS INC. | | 206.83% | 21.0 | |
| 55 | ENDOCYTE INC | | 205.88% | -36.0 | |
 | 56 | Mirati Therapeutics Inc. | | 205.60% | 144.0 | |
 | 57 | Endo International plc | | 205.39% | 1.0 |  |
 | 58 | Amphastar Pharmaceuticals Inc. | | 204.90% | -16.0 | |
 | 59 | Avalo Therapeutics Inc. | | 204.80% | 0.0 | |
 | 60 | Epizyme Inc. | | 204.44% | -14.0 | |
| 61 | Citius Pharmaceuticals Inc. | | 203.56% | 37.0 | |
 | 62 | Cryoport Inc. | | 201.99% | 176.0 | |
 | 63 | VBI Vaccines Inc BC | | 200.61% | 0.0 |  |
| 64 | Myovant Sciences Ltd. | | 199.71% | 0.0 | |
 | 65 | ARDELYX INC. | | 198.64% | 2.0 | |
 | 66 | Neoleukin Therapeutics Inc. | | 197.01% | -48.0 | |
 | 67 | Calithera Biosciences Inc. | | 196.57% | 24.0 | |
 | 68 | Aptevo Therapeutics Inc. | | 194.81% | 0.0 | |
 | 69 | AMICUS THERAPEUTICS INC. | | 192.79% | -42.0 | |
 | 70 | CymaBay Therapeutics Inc. | | 191.88% | 0.0 | |
 | 71 | Aeglea BioTherapeutics Inc. | | 191.84% | -46.0 | |
 | 72 | Lexaria Bioscience Corp. | | 191.78% | 182.0 | |
 | 73 | Edesa Biotech Inc. | | 191.41% | -43.0 | |
 | 74 | Apellis Pharmaceuticals Inc. | | 190.58% | 0.0 | |
 | 75 | Zynerba Pharmaceuticals Inc. | | 188.76% | 41.0 | |
 | 76 | TherapeuticsMD Inc. | | 187.18% | 11.0 | |
 | 77 | PROTHENA CORP PUBLIC LTD CO | | 186.90% | 4.0 | |
 | 78 | ALIMERA SCIENCES INC | | 185.82% | -5.0 | |
 | 79 | SYNLOGIC INC. | | 185.18% | -44.0 | |
| 80 | Kura Oncology Inc. | | 182.26% | -1.0 | |
 | 81 | KalVista Pharmaceuticals Inc. | | 181.97% | 0.0 | |
 | 82 | Moleculin Biotech Inc. | | 179.77% | -59.0 | |
 | 83 | OPKO HEALTH INC. | | 179.50% | -36.0 | |
| 84 | FIVE PRIME THERAPEUTICS INC. | | 179.04% | -69.0 | |
| 85 | ARENA PHARMACEUTICALS INC | | 178.82% | 25.0 | |
 | 86 | SUPERNUS PHARMACEUTICALS INC. | | 177.85% | -27.0 | |
 | 87 | Anixa Biosciences Inc | | 177.67% | 0.0 | |
 | 88 | ROCKWELL MEDICAL INC. | | 176.34% | -51.0 | |
 | 89 | Savara Inc | | 176.24% | 159.0 | |
 | 90 | Corbus Pharmaceuticals Holdings Inc. | | 175.83% | 124.0 | |
 | 91 | DURECT CORP | | 175.33% | 125.0 | |
 | 92 | Xencor Inc | | 175.05% | -44.0 | |
 | 93 | Xenetic Biosciences Inc. | | 174.84% | 0.0 | |
| 94 | JUNIPER PHARMACEUTICALS INC | | 173.68% | -33.0 | |
 | 95 | SEELOS THERAPEUTICS INC. | | 173.41% | 165.0 | |
 | 96 | RELIV INTERNATIONAL INC | | 173.22% | -11.0 | |
| 97 | Corvus Pharmaceuticals Inc. | | 172.38% | -80.0 | |
 | 98 | G1 Therapeutics Inc. | | 171.87% | 0.0 | |
| 99 | ALEXION PHARMACEUTICALS INC. | | 171.75% | -22.0 | |
| 100 | Assertio Therapeutics Inc | | 170.43% | -61.0 | |
 | 101 | SPECTRUM PHARMACEUTICALS INC | | 167.38% | 28.0 | |
 | 102 | CUMBERLAND PHARMACEUTICALS INC | | 166.30% | -62.0 | |
 | 103 | Guardion Health Sciences Inc. | | 165.48% | 187.0 | |
 | 104 | Minerva Neurosciences Inc. | | 165.25% | -39.0 | |
 | 105 | Protagonist Therapeutics Inc | | 165.01% | 0.0 | |
 | 106 | LIFECORE BIOMEDICAL INC. \DE\ | | 164.92% | -6.0 | |
 | 107 | ARROWHEAD PHARMACEUTICALS INC. | | 164.69% | 27.0 | |
 | 108 | Esperion Therapeutics Inc. | | 163.06% | -82.0 | |
 | 109 | OPIANT PHARMACEUTICALS INC. | | 162.44% | 161.0 | |
| 110 | Dicerna Pharmaceuticals Inc | | 162.36% | 0.0 | |
 | 111 | Mersana Therapeutics Inc. | | 161.40% | 0.0 | |
 | 112 | CV Sciences Inc. | | 160.33% | 37.0 | |
 | 113 | OTONOMY INC. | | 160.00% | -53.0 | |
 | 114 | LIGAND PHARMACEUTICALS INC | | 158.65% | -19.0 | |
 | 115 | Arbutus Biopharma Corp | | 157.23% | 96.0 | |
| 116 | Altrazeal Life Sciences Inc. | | 156.10% | 103.0 | |
 | 117 | BeiGene Ltd. | | 153.89% | -72.0 | |
| 118 | Allergan plc | | 152.73% | -28.0 | |
 | 119 | Vanda Pharmaceuticals Inc. | | 150.56% | -13.0 | |
 | 120 | VYNE Therapeutics Inc. | | 149.45% | 0.0 | |
| 121 | Aimmune Therapeutics Inc. | | 147.81% | 0.0 | |
| 122 | Tonix Pharmaceuticals Holding Corp. | | 146.85% | 64.0 | |
 | 123 | Tempest Therapeutics Inc. | | 146.51% | -26.0 | |
| 124 | NANOVIRICIDES INC. | | 146.36% | 1.0 | |
| 125 | Pfenex Inc. | | 145.85% | -89.0 | |
 | 126 | VERTEX PHARMACEUTICALS INC MA | | 145.51% | 9.0 | |
 | 127 | BIOMARIN PHARMACEUTICAL INC | | 145.44% | 43.0 | |
 | 128 | Theravance Biopharma Inc. | | 145.24% | -99.0 | |
| 129 | Neurotrope Inc. | | 144.30% | -67.0 | |
 | 130 | CNBX Pharmaceuticals Inc. | | 143.91% | 0.0 | |
 | 131 | Sarepta Therapeutics Inc. | | 143.06% | -11.0 | |
 | 132 | CHINA PHARMA HOLDINGS INC. | | 142.66% | 0.0 | |
 | 133 | NATURES SUNSHINE PRODUCTS INC | | 142.38% | -44.0 | |
 | 134 | OMEROS CORP | | 142.12% | 34.0 | |
 | 135 | BIO-PATH HOLDINGS INC | | 142.03% | 3.0 | |
| 136 | Ra Pharmaceuticals Inc. | | 141.56% | -116.0 | |
 | 137 | Wave Life Sciences Ltd. | | 140.92% | -84.0 | |
 | 138 | Syndax Pharmaceuticals Inc | | 139.40% | -39.0 | |
 | 139 | Histogen Inc. | | 136.45% | 9.0 | |
 | 140 | DMK PHARMACEUTICALS Corp | | 134.31% | -4.0 | |
 | 141 | ACADIA PHARMACEUTICALS INC | | 132.36% | -91.0 | |
 | 142 | OptiNose Inc. | | 132.30% | 0.0 | |
 | 143 | Syros Pharmaceuticals Inc. | | 131.18% | -71.0 | |
| 144 | Oncternal Therapeutics Inc. | | 130.49% | -16.0 | |
 | 145 | GYRE THERAPEUTICS INC. | | 130.03% | 38.0 | |
| 146 | ARQULE INC | | 129.95% | -3.0 | |
 | 147 | PERRIGO Co plc | | 127.59% | 16.0 | |
 | 148 | COLLEGIUM PHARMACEUTICAL INC | | 124.69% | -47.0 | |
 | 149 | Larimar Therapeutics Inc. | | 124.27% | -105.0 | |
 | 150 | Biohaven Pharmaceutical Holding Co Ltd. | | 123.36% | 0.0 | |
| 151 | Nabriva Therapeutics plc | | 122.07% | -44.0 | |
 | 152 | Travere Therapeutics Inc. | | 118.84% | -40.0 | |
| 153 | ALDER BIOPHARMACEUTICALS INC | | 117.10% | -120.0 | |
 | 154 | EYENOVIA INC. | | 117.04% | 0.0 | |
 | 155 | IVERIC bio Inc. | | 114.81% | 0.0 | |
| 156 | Dova Pharmaceuticals Inc. | | 114.43% | 0.0 | |
 | 157 | INFINITY PHARMACEUTICALS INC. | | 113.39% | -46.0 | |
| 158 | AKCEA THERAPEUTICS INC. | | 111.18% | 0.0 | |
 | 159 | EXICURE INC. | | 110.59% | 0.0 | |
 | 160 | Xenon Pharmaceuticals Inc. | | 110.47% | -136.0 | |
 | 161 | Aravive Inc. | | 109.80% | -44.0 | |
 | 162 | PFIZER INC | | 106.96% | 0.0 | |
 | 163 | AGILE THERAPEUTICS INC | | 105.36% | -81.0 | |
 | 164 | ChemoCentryx Inc. | | 102.99% | 20.0 | |
 | 165 | AVADEL PHARMACEUTICALS PLC | | 102.44% | 30.0 | |
 | 166 | ORAGENICS INC | | 101.87% | 78.0 | |
 | 167 | Altimmune Inc. | | 100.28% | -36.0 | |
| 168 | Flexion Therapeutics Inc | | 99.63% | -100.0 | |
 | 169 | KINETA INC. DE | | 97.96% | -118.0 | |
 | 170 | CHINOOK THERAPEUTICS INC. | | 97.55% | -33.0 | |
| 171 | ARATANA THERAPEUTICS INC. | | 96.41% | -45.0 | |
| 172 | AKORN INC | | 94.33% | -40.0 | |
| 173 | United Cannabis Corp | | 94.02% | 115.0 | |
 | 174 | ANI PHARMACEUTICALS INC | | 92.22% | -56.0 | |
 | 175 | F-star Therapeutics Inc. | | 91.74% | -19.0 | |
 | 176 | JOHNSON & JOHNSON | | 83.02% | 0.0 | |
 | 177 | ATOSSA THERAPEUTICS INC. | | 81.20% | 0.0 | |
 | 178 | Karyopharm Therapeutics Inc. | | 81.10% | 0.0 | |
 | 179 | CASSAVA SCIENCES INC | | 79.77% | -101.0 | |
| 180 | PORTOLA PHARMACEUTICALS INC | | 79.38% | 9.0 | |
 | 181 | ORAMED PHARMACEUTICALS INC. | | 78.22% | -54.0 | |
 | 182 | BRISTOL MYERS SQUIBB CO | | 77.73% | -67.0 | |
 | 183 | AGIOS PHARMACEUTICALS INC. | | 77.50% | -129.0 | |
| 184 | Achaogen Inc. | | 77.32% | -51.0 | |
 | 185 | Salarius Pharmaceuticals Inc. | | 76.46% | 0.0 | |
 | 186 | Imunon Inc. | | 74.72% | 0.0 | |
 | 187 | Avid Bioservices Inc. | | 73.74% | -7.0 | |
 | 188 | Lipocine Inc. | | 73.66% | -114.0 | |
 | 189 | LANNETT CO INC | | 72.92% | -35.0 | |
 | 190 | Lifevantage Corp | | 69.90% | -30.0 | |
| 191 | Capstone Therapeutics Corp. | | 68.03% | 16.0 | |
| 192 | Optec International Inc. | | 67.83% | 0.0 | |
 | 193 | ROCKET PHARMACEUTICALS INC. | | 67.62% | -51.0 | |
| 194 | SteadyMed Ltd. | | 66.77% | 9.0 | |
| 195 | Cellectar Biosciences Inc. | | 65.86% | -140.0 | |
 | 196 | CohBar Inc. | | 64.73% | -116.0 | |
 | 197 | IONIS PHARMACEUTICALS INC | | 63.62% | 1.0 | |
 | 198 | Orgenesis Inc. | | 62.70% | -11.0 | |
 | 199 | Eterna Therapeutics Inc. | | 61.63% | -11.0 | |
 | 200 | PHIBRO ANIMAL HEALTH CORP | | 59.83% | -23.0 | |
| 201 | Kintara Therapeutics Inc. | | 59.61% | 0.0 | |
 | 202 | XOMA Corp | | 58.39% | 59.0 | |
 | 203 | SOLIGENIX INC. | | 58.26% | -99.0 | |
 | 204 | BELLICUM PHARMACEUTICALS INC | | 57.74% | -80.0 | |
| 205 | CELGENE CORP DE | | 57.31% | -38.0 | |
 | 206 | Enveric Biosciences Inc. | | 54.99% | 0.0 | |
| 207 | MELINTA THERAPEUTICS INC. NEW | | 52.78% | 0.0 | |
 | 208 | Sonnet BioTherapeutics Holdings Inc. | | 52.36% | -27.0 | |
 | 209 | Clovis Oncology Inc. | | 52.35% | 27.0 | |
 | 210 | Zoetis Inc. | | 51.75% | -39.0 | |
 | 211 | Verastem Inc. | | 51.52% | 0.0 | |
 | 212 | ELI LILLY & Co | | 50.97% | -68.0 | |
| 213 | PROGENICS PHARMACEUTICALS INC | | 50.91% | 0.0 | |
 | 214 | Statera Biopharma Inc. | | 50.50% | -162.0 | |
 | 215 | uniQure N.V. | | 45.96% | -24.0 | |
 | 216 | Paratek Pharmaceuticals Inc. | | 43.05% | -19.0 | |
 | 217 | Akebia Therapeutics Inc. | | 42.07% | -13.0 | |
| 218 | BIOVIE INC. | | 36.96% | 0.0 | |
 | 219 | Bausch Health Companies Inc. | | 36.88% | 0.0 | |
| 220 | Teligent Inc. | | 36.74% | -55.0 | |
 | 221 | SCYNEXIS INC | | 33.48% | -70.0 | |
| 222 | Fibrocell Science Inc. | | 33.35% | -26.0 | |
 | 223 | IntelGenx Technologies Corp. | | 33.17% | -70.0 | |
 | 224 | Matinas BioPharma Holdings Inc. | | 31.78% | -77.0 | |
 | 225 | CYTOKINETICS INC | | 25.53% | -123.0 | |
 | 226 | Checkpoint Therapeutics Inc. | | 22.99% | -142.0 | |
 | 227 | Jaguar Health Inc. | | 22.06% | 46.0 | |
 | 228 | CytomX Therapeutics Inc. | | 21.25% | -55.0 | |
 | 229 | Sio Gene Therapies Inc. | | 21.21% | -116.0 | |
| 230 | SOPHIRIS BIO INC. | | 19.65% | -69.0 | |
 | 231 | Ainos Inc. | | 18.61% | 27.0 | |
 | 232 | Emmaus Life Sciences Inc. | | 18.54% | 43.0 | |
 | 233 | Ocuphire Pharma Inc. | | 17.82% | -139.0 | |
| 234 | Viking Therapeutics Inc. | | 16.74% | -28.0 | |
 | 235 | HERON THERAPEUTICS INC. DE | | 16.64% | 28.0 | |
| 236 | Health-Right Discoveries Inc. | | 15.93% | 35.0 | |
| 237 | Adamas Pharmaceuticals Inc | | 15.84% | -196.0 | |
 | 238 | NEKTAR THERAPEUTICS | | 11.72% | -37.0 | |
 | 239 | Seres Therapeutics Inc. | | 9.44% | -84.0 | |
 | 240 | Viracta Therapeutics Inc. | | 7.65% | -83.0 | |
| 241 | RENOVARO BIOSCIENCES INC. | | 6.48% | 18.0 | |
 | 242 | Hepion Pharmaceuticals Inc. | | 4.97% | 0.0 | |
 | 243 | PIERIS PHARMACEUTICALS INC. | | 0.58% | -103.0 | |
 | 244 | Ayala Pharmaceuticals Inc. | | -0.16% | -122.0 | |
 | 245 | Monopar Therapeutics | | -0.19% | 0.0 | |
 | 246 | Societal CDMO Inc. | | -0.27% | -88.0 | |
| 247 | Axsome Therapeutics Inc. | | -0.70% | -65.0 | |
 | 248 | iBio Inc. | | -2.55% | -102.0 | |
| 249 | Theriva Biologics Inc. | | -4.31% | -8.0 | |
 | 250 | TG THERAPEUTICS INC. | | -5.08% | -33.0 | |
 | 251 | Pulmatrix Inc. | | -5.69% | -14.0 | |
| 252 | TESARO Inc. | | -9.38% | -133.0 | |
| 253 | Dermira Inc. | | -9.43% | -177.0 | |
 | 254 | LEXICON PHARMACEUTICALS INC. | | -9.61% | 0.0 | |
| 255 | LIXTE BIOTECHNOLOGY HOLDINGS INC. | | -11.14% | 26.0 | |
 | 256 | NightHawk Biosciences Inc. | | -12.89% | -46.0 | |
| 257 | VIVUS INC | | -17.27% | -63.0 | |
 | 258 | Regulus Therapeutics Inc. | | -18.84% | -65.0 | |
 | 259 | TREVENA INC | | -20.90% | -83.0 | |
| 260 | Old API Wind-down Ltd. | | -21.15% | -70.0 | |
| 261 | Corium International Inc. | | -25.94% | -43.0 | |
| 262 | Impax Laboratories LLC | | -26.68% | -83.0 | |
 | 263 | Actinium Pharmaceuticals Inc. | | -26.84% | -91.0 | |
 | 264 | CTI BIOPHARMA CORP | | -27.51% | -39.0 | |
 | 265 | PLx Pharma Winddown Corp. | | -27.91% | -90.0 | |
 | 266 | HARROW INC. | | -33.12% | -53.0 | |
 | 267 | NovaBay Pharmaceuticals Inc. | | -33.49% | -62.0 | |
| 268 | ARRAY BIOPHARMA INC | | -35.38% | -35.0 | |
| 269 | TYME TECHNOLOGIES INC. | | -35.50% | 0.0 | |
 | 270 | ATHERSYS INC NEW | | -36.29% | -62.0 | |
 | 271 | ImmunoGen Inc. | | -41.76% | -37.0 | |
 | 272 | International Stem Cell CORP | | -43.19% | -131.0 | |
 | 273 | INTEGRATED BIOPHARMA INC | | -43.24% | -44.0 | |
 | 274 | OCULAR THERAPEUTIX INC | | -43.46% | -135.0 | |
 | 275 | LEAP THERAPEUTICS INC. | | -46.32% | 0.0 | |
| 276 | Neos Therapeutics Inc. | | -50.94% | -37.0 | |
 | 277 | Astria Therapeutics Inc. | | -59.01% | -111.0 | |
 | 278 | SELLAS Life Sciences Group Inc. | | -62.15% | -109.0 | |
 | 279 | INTERCEPT PHARMACEUTICALS INC. | | -69.76% | -87.0 | |
 | 280 | Clearside Biomedical Inc. | | -74.33% | -223.0 | |
 | 281 | MusclePharm Corp | | -80.52% | -69.0 | |
| 282 | Rezolute Inc. | | -88.12% | -83.0 | |
| 283 | OncoMed Pharmaceuticals Inc | | -91.10% | -57.0 | |
 | 284 | Adhera Therapeutics Inc. | | -91.42% | 0.0 | |
 | 285 | AMARIN CORP PLC\UK | | -92.63% | -61.0 | |
| 286 | Zyla Life Sciences | | -97.91% | -58.0 | |
 | 287 | KIORA PHARMACEUTICALS INC | | -108.25% | -40.0 | |
| 288 | KERYX BIOPHARMACEUTICALS INC | | -113.14% | -43.0 | |
| 289 | CARDAX INC. | | -114.08% | -22.0 | |
 | 290 | AYTU BIOPHARMA INC | | -120.23% | -67.0 | |
| 291 | Strongbridge Biopharma plc | | -121.93% | 0.0 | |
| 292 | EOM Pharmaceutical Holdings Inc. | | -134.83% | -60.0 | |
| 293 | Marker Therapeutics Inc. | | -139.95% | 0.0 | |
 | 294 | PUMA BIOTECHNOLOGY INC. | | -144.21% | -132.0 | |
| 295 | Bellerophon Therapeutics Inc. | | -155.57% | -110.0 | |
| 296 | NeuroBo Pharmaceuticals Inc. | | -156.26% | -193.0 | |
| 297 | ZEVRA THERAPEUTICS INC. | | -175.23% | -75.0 | |
 | 298 | RELMADA THERAPEUTICS INC. | | -179.18% | -190.0 | |
 | 299 | Innovation Pharmaceuticals Inc. | | -183.40% | -68.0 | |
 | 300 | NVN Liquidation Inc. | | -184.08% | -91.0 | |
 | 301 | ABVC BIOPHARMA INC. | | -187.41% | -16.0 | |
 | 302 | AVEO PHARMACEUTICALS INC. | | -191.48% | -62.0 | |
| 303 | CQENS Technologies Inc. | | -193.00% | -46.0 | |
| 304 | Evofem Biosciences Inc. | | -193.02% | -174.0 | |
 | 305 | SIGA TECHNOLOGIES INC | | -193.32% | -55.0 | |
| 306 | MABVAX THERAPEUTICS HOLDINGS INC. | | -207.61% | -64.0 | |
 | 307 | CorMedix Inc. | | -209.28% | -133.0 | |
| 308 | NORTHWEST BIOTHERAPEUTICS INC | | -214.61% | -56.0 | |
 | 309 | vTv Therapeutics Inc. | | -234.28% | -107.0 | |
| 310 | PROTEO INC | | -240.22% | -59.0 | |
| 311 | Genprex Inc. | | -246.55% | 0.0 | |
 | 312 | CEN BIOTECH INC | | -252.51% | -47.0 | |
 | 313 | MANNKIND CORP | | -253.55% | -78.0 | |
| 314 | ProtoKinetix Inc. | | -262.93% | -58.0 | |
 | 315 | Vistagen Therapeutics Inc. | | -270.14% | -24.0 | |
| 316 | AXIM BIOTECHNOLOGIES INC. | | -280.77% | 0.0 | |
| 317 | ENDONOVO THERAPEUTICS INC. | | -290.14% | 0.0 | |
| 318 | NANOMIX Corp | | -290.46% | -52.0 | |
 | 319 | Phio Pharmaceuticals Corp. | | -292.29% | -198.0 | |
| 320 | REGENERX BIOPHARMACEUTICALS INC | | -297.28% | -58.0 | |
| 321 | SANGUI BIOTECH INTERNATIONAL INC | | -341.42% | 0.0 | |
 | 322 | Ampio Pharmaceuticals Inc. | | -341.56% | -92.0 | |
| 323 | Oncolix Inc. | | -361.38% | -31.0 | |
 | 324 | Innovation1 Biotech Inc. | | -374.26% | 0.0 | |
| 325 | Retrieve Medical Holdings Inc. | | -385.21% | 0.0 | |
| 326 | Cell Source Inc. | | -388.60% | 0.0 | |
 | 327 | Kaya Holdings Inc. | | -400.75% | -50.0 | |
 | 328 | NEUROPATHIX INC. | | -404.66% | -60.0 | |
 | 329 | Onconova Therapeutics Inc. | | -410.74% | -109.0 | |
| 330 | Regen BioPharma Inc | | -414.22% | -41.0 | |
 | 331 | GeoVax Labs Inc. | | -418.34% | -49.0 | |
| 332 | HypGen Inc | | -447.54% | -83.0 | |
| 333 | Skye Bioscience Inc. | | -467.00% | -53.0 | |
 | 334 | Biostax Corp. | | -470.35% | -48.0 | |
| 335 | RespireRx Pharmaceuticals Inc. | | -496.65% | -51.0 | |
| 336 | Anthera Pharmaceuticals Inc | | -565.77% | -83.0 | |
| 337 | Greater Cannabis Company Inc. | | -605.37% | 0.0 | |
| 338 | Propanc Biopharma Inc. | | -616.63% | -51.0 | |
 | 339 | 9 METERS BIOPHARMA INC. | | -680.41% | -124.0 | |
| 340 | GlobeStar Therapeutics Corp | | -818.04% | 0.0 | |
| 341 | Wellness Center USA Inc. | | -939.26% | 0.0 | |
| 342 | Q BioMed Inc. | | -2145.68% | -68.0 | |
