 | 1 | Theravance Biopharma Inc. |  | 587.15% | 196.0 |  |
 | 2 | CHIMERIX INC |  | 406.73% | 407.0 |  |
 | 3 | Ocuphire Pharma Inc. |  | 376.54% | 413.0 |  |
 | 4 | Kiniksa Pharmaceuticals Ltd. |  | 330.58% | 240.0 |  |
 | 5 | Zomedica Corp. |  | 303.25% | 7.0 |  |
 | 6 | XBiotech Inc. |  | 301.84% | 0.0 |  |
 | 7 | ARS Pharmaceuticals Inc. |  | 299.94% | 66.0 |  |
 | 8 | SIGA TECHNOLOGIES INC |  | 297.01% | 22.0 |  |
 | 9 | Nuvation Bio Inc. |  | 296.10% | 8.0 |  |
 | 10 | ESSA Pharma Inc. |  | 293.57% | 14.0 |  |
 | 11 | EQRx Inc. |  | 291.84% | 60.0 |  |
 | 12 | CORCEPT THERAPEUTICS INC |  | 290.00% | -8.0 |  |
 | 13 | DICE Therapeutics Inc. |  | 286.99% | 19.0 |  |
 | 14 | Nuvalent Inc. |  | 284.63% | 11.0 |  |
 | 15 | Xenon Pharmaceuticals Inc. |  | 283.33% | 11.0 |  |
 | 16 | Tyra Biosciences Inc. |  | 282.76% | -9.0 |  |
 | 17 | Design Therapeutics Inc. |  | 280.65% | -8.0 |  |
 | 18 | Terns Pharmaceuticals Inc. |  | 279.87% | 54.0 |  |
 | 19 | Jazz Pharmaceuticals plc |  | 279.48% | 2.0 |  |
 | 20 | POINT Biopharma Global Inc. |  | 279.42% | 8.0 |  |
 | 21 | Morphic Holding Inc. |  | 278.32% | 139.0 |  |
 | 22 | Rezolute Inc. |  | 278.09% | 257.0 |  |
 | 23 | Karuna Therapeutics Inc. |  | 276.47% | 45.0 |  |
 | 24 | ANAPTYSBIO INC |  | 274.63% | -13.0 |  |
 | 25 | Astria Therapeutics Inc. |  | 273.79% | 319.0 |  |
 | 26 | MEDICINOVA INC |  | 273.45% | -3.0 |  |
 | 27 | Edgewise Therapeutics Inc. |  | 272.68% | 2.0 |  |
 | 28 | ATOSSA THERAPEUTICS INC. |  | 272.56% | -12.0 |  |
 | 29 | Atea Pharmaceuticals Inc. |  | 270.43% | -24.0 |  |
 | 30 | CATALYST PHARMACEUTICALS INC. |  | 266.12% | -8.0 |  |
 | 31 | Lantern Pharma Inc. |  | 266.04% | -4.0 |  |
 | 32 | Synaptogenix Inc. |  | 264.78% | 58.0 |  |
 | 33 | NANOVIRICIDES INC. |  | 264.30% | 3.0 |  |
 | 34 | CASSAVA SCIENCES INC |  | 260.29% | -3.0 |  |
 | 35 | Theseus Pharmaceuticals Inc. |  | 258.17% | -25.0 |  |
 | 36 | Ventyx Biosciences Inc. |  | 257.00% | 30.0 |  |
 | 37 | Cyteir Therapeutics Inc. |  | 256.65% | 2.0 |  |
 | 38 | Lipocine Inc. |  | 256.18% | 23.0 |  |
 | 39 | IDEAYA Biosciences Inc. |  | 253.86% | 100.0 |  |
 | 40 | XOMA Corp |  | 250.34% | 3.0 |  |
 | 41 | Eliem Therapeutics Inc. |  | 249.21% | 9.0 |  |
 | 42 | Syndax Pharmaceuticals Inc |  | 248.28% | -24.0 |  |
 | 43 | Xencor Inc |  | 247.33% | -9.0 |  |
 | 44 | China Health Industries Holdings Inc. |  | 246.91% | 30.0 |  |
 | 45 | AbCellera Biologics Inc. |  | 246.57% | 49.0 |  |
 | 46 | Vanda Pharmaceuticals Inc. |  | 246.20% | 9.0 |  |
 | 47 | UNITED THERAPEUTICS Corp |  | 245.78% | 57.0 |  |
 | 48 | VERTEX PHARMACEUTICALS INC MA |  | 243.37% | 48.0 |  |
 | 49 | REGENERON PHARMACEUTICALS INC. |  | 241.66% | 29.0 |  |
 | 50 | ABBOTT LABORATORIES |  | 241.28% | 20.0 |  |
 | 51 | AGIOS PHARMACEUTICALS INC. |  | 240.58% | -50.0 |  |
 | 52 | Merck & Co. Inc. |  | 240.50% | 40.0 |  |
 | 53 | Janux Therapeutics Inc. |  | 239.63% | -39.0 |  |
 | 54 | Lyell Immunopharma Inc. |  | 239.39% | 84.0 |  |
 | 55 | AbbVie Inc. |  | 237.76% | 57.0 |  |
 | 56 | PMV Pharmaceuticals Inc. |  | 237.39% | -5.0 |  |
 | 57 | Anebulo Pharmaceuticals Inc. |  | 237.25% | 246.0 |  |
 | 58 | Kura Oncology Inc. |  | 237.20% | 1.0 |  |
 | 59 | Acasti Pharma Inc. |  | 236.83% | 58.0 |  |
 | 60 | TherapeuticsMD Inc. |  | 236.59% | 364.0 |  |
 | 61 | RAPT Therapeutics Inc. |  | 235.29% | 32.0 |  |
 | 62 | Adicet Bio Inc. |  | 234.68% | 21.0 |  |
 | 63 | Avidity Biosciences Inc. |  | 234.17% | 43.0 |  |
 | 64 | Forte Biosciences Inc. |  | 234.14% | 52.0 |  |
 | 65 | ACELRX PHARMACEUTICALS INC |  | 233.12% | 347.0 |  |
 | 66 | ELITE PHARMACEUTICALS INC NV |  | 231.97% | 0.0 |  |
 | 67 | Aerovate Therapeutics Inc. |  | 231.18% | -54.0 |  |
 | 68 | Ainos Inc. |  | 229.60% | 261.0 |  |
 | 69 | Disc Medicine Inc. |  | 229.59% | 96.0 |  |
 | 70 | Organon & Co. |  | 228.91% | 33.0 |  |
 | 71 | Carisma Therapeutics Inc. |  | 228.86% | 86.0 |  |
 | 72 | OMEROS CORP |  | 228.03% | -69.0 |  |
 | 73 | Verona Pharma plc |  | 227.20% | 105.0 |  |
 | 74 | INTEGRATED BIOPHARMA INC |  | 224.19% | 100.0 |  |
 | 75 | Arcus Biosciences Inc. |  | 222.55% | 150.0 |  |
 | 76 | Keros Therapeutics Inc. |  | 221.63% | -29.0 |  |
 | 77 | Sage Therapeutics Inc. |  | 221.59% | -15.0 |  |
 | 78 | Aurinia Pharmaceuticals Inc. |  | 219.68% | 48.0 |  |
 | 79 | Kinnate Biopharma Inc. |  | 219.16% | -39.0 |  |
 | 80 | Larimar Therapeutics Inc. |  | 218.99% | 143.0 |  |
 | 81 | Greenwich LifeSciences Inc. |  | 216.93% | -66.0 |  |
 | 82 | Homology Medicines Inc. |  | 215.74% | 122.0 |  |
 | 83 | LIGAND PHARMACEUTICALS INC |  | 214.32% | 110.0 |  |
 | 84 | Xenetic Biosciences Inc. |  | 214.28% | 1.0 |  |
 | 85 | PLIANT THERAPEUTICS INC. |  | 213.85% | 56.0 |  |
 | 86 | Anixa Biosciences Inc |  | 212.93% | -5.0 |  |
 | 87 | NextCure Inc. |  | 212.16% | -29.0 |  |
 | 88 | KalVista Pharmaceuticals Inc. |  | 210.90% | -50.0 |  |
 | 89 | Amphastar Pharmaceuticals Inc. |  | 209.30% | 73.0 |  |
 | 90 | Reneo Pharmaceuticals Inc. |  | 206.12% | -37.0 |  |
 | 91 | Immuneering Corp |  | 205.27% | -37.0 |  |
 | 92 | Altimmune Inc. |  | 204.67% | 41.0 |  |
 | 93 | Intra-Cellular Therapies Inc. |  | 203.93% | 110.0 |  |
 | 94 | ROCKET PHARMACEUTICALS INC. |  | 202.08% | 11.0 |  |
 | 95 | Aadi Bioscience Inc. |  | 201.66% | 122.0 |  |
 | 96 | Tonix Pharmaceuticals Holding Corp. |  | 201.56% | 26.0 |  |
 | 97 | Repare Therapeutics Inc. |  | 201.28% | 85.0 |  |
 | 98 | Olema Pharmaceuticals Inc. |  | 200.36% | -56.0 |  |
 | 99 | ENANTA PHARMACEUTICALS INC |  | 199.90% | -24.0 |  |
 | 100 | IO Biotech Inc. |  | 197.92% | -24.0 |  |
 | 101 | BIOMARIN PHARMACEUTICAL INC |  | 197.62% | 58.0 |  |
 | 102 | COMPASS Pathways plc |  | 194.50% | -39.0 |  |
 | 103 | Ovid Therapeutics Inc. |  | 194.46% | -101.0 |  |
 | 104 | Moleculin Biotech Inc. |  | 193.44% | -58.0 |  |
 | 105 | Sensei Biotherapeutics Inc. |  | 193.39% | -57.0 |  |
 | 106 | PARDES BIOSCIENCES INC. |  | 192.98% | -86.0 |  |
 | 107 | Viking Therapeutics Inc. |  | 188.60% | -55.0 |  |
 | 108 | ALX ONCOLOGY HOLDINGS INC |  | 188.41% | -67.0 |  |
 | 109 | CorMedix Inc. |  | 188.36% | 0.0 |  |
 | 110 | Ayala Pharmaceuticals Inc. |  | 186.16% | 62.0 |  |
 | 111 | Viracta Therapeutics Inc. |  | 186.03% | 0.0 |  |
 | 112 | DYNAVAX TECHNOLOGIES CORP | | 185.65% | 0.0 |  |
 | 113 | Entrada Therapeutics Inc. | | 185.18% | -94.0 |  |
 | 114 | Harmony Biosciences Holdings Inc. | | 185.05% | 142.0 |  |
 | 115 | IVERIC bio Inc. | | 183.82% | -27.0 |  |
 | 116 | Nkarta Inc. | | 183.41% | -15.0 |  |
 | 117 | Fulcrum Therapeutics Inc. | | 182.46% | 3.0 |  |
 | 118 | Verrica Pharmaceuticals Inc. | | 179.66% | 214.0 |  |
 | 119 | Endo International plc | | 179.58% | -10.0 |  |
 | 120 | Prelude Therapeutics Inc | | 179.36% | -22.0 |  |
 | 121 | Indaptus Therapeutics Inc. | | 178.36% | -30.0 |  |
 | 122 | PROCYON CORP | | 177.40% | 6.0 |  |
 | 123 | HCW Biologics Inc. | | 176.10% | -78.0 |  |
 | 124 | GeoVax Labs Inc. | | 175.82% | 0.0 |  |
 | 125 | Protagonist Therapeutics Inc | | 173.72% | 20.0 |  |
 | 126 | Cogent Biosciences Inc. | | 173.22% | -31.0 |  |
 | 127 | Immix Biopharma Inc. | | 172.74% | 166.0 |  |
 | 128 | Shattuck Labs Inc. | | 171.34% | -59.0 |  |
 | 129 | ATAI Life Sciences N.V. | | 171.25% | -10.0 |  |
 | 130 | Savara Inc | | 171.06% | 18.0 |  |
 | 131 | Thorne Healthtech Inc. | | 170.97% | 38.0 |  |
 | 132 | Inozyme Pharma Inc. | | 170.59% | 23.0 |  |
 | 133 | OPKO HEALTH INC. | | 169.60% | 31.0 |  |
 | 134 | LUMOS PHARMA INC. | | 168.04% | -16.0 |  |
 | 135 | Kronos Bio Inc. | | 166.17% | 5.0 |  |
 | 136 | Theriva Biologics Inc. | | 165.61% | -69.0 |  |
 | 137 | Cartesian Therapeutics Inc. | | 165.39% | 222.0 |  |
 | 138 | Assertio Holdings Inc. | | 165.38% | 161.0 |  |
 | 139 | CohBar Inc. | | 163.18% | 8.0 |  |
 | 140 | Aclaris Therapeutics Inc. | | 162.19% | 55.0 |  |
 | 141 | CHINOOK THERAPEUTICS INC. | | 161.63% | 1.0 |  |
 | 142 | NATURES SUNSHINE PRODUCTS INC | | 160.92% | 41.0 |  |
 | 143 | NGM BIOPHARMACEUTICALS INC | | 159.72% | 7.0 |  |
 | 144 | Werewolf Therapeutics Inc. | | 158.07% | -12.0 |  |
 | 145 | Zentalis Pharmaceuticals Inc. | | 157.91% | 41.0 |  |
 | 146 | Matinas BioPharma Holdings Inc. | | 157.28% | 10.0 |  |
 | 147 | Longboard Pharmaceuticals Inc. | | 156.66% | -87.0 |  |
 | 148 | AMARIN CORP PLC\UK | | 156.02% | 53.0 |  |
 | 149 | Aptevo Therapeutics Inc. | | 154.36% | 237.0 |  |
 | 150 | Neoleukin Therapeutics Inc. | | 152.19% | 0.0 |  |
 | 151 | EAGLE PHARMACEUTICALS INC. | | 150.96% | 24.0 |  |
 | 152 | Rain Oncology Inc. | | 150.85% | -25.0 |  |
 | 153 | Erasca Inc. | | 150.54% | -66.0 |  |
 | 154 | Arcturus Therapeutics Holdings Inc. | | 150.46% | 141.0 |  |
 | 155 | Vistagen Therapeutics Inc. | | 150.28% | -47.0 |  |
 | 156 | Organogenesis Holdings Inc. | | 149.27% | 42.0 |  |
 | 157 | Dyne Therapeutics Inc. | | 147.56% | -14.0 |  |
 | 158 | EXICURE INC. | | 145.49% | 242.0 |  |
 | 159 | Bolt Biotherapeutics Inc. | | 145.43% | 9.0 |  |
 | 160 | uniQure N.V. | | 145.03% | -95.0 |  |
 | 161 | Orgenesis Inc. | | 144.66% | 74.0 |  |
 | 162 | Lexaria Bioscience Corp. | | 142.97% | -118.0 |  |
 | 163 | Oncotelic Therapeutics Inc. | | 142.12% | 189.0 |  |
 | 164 | SPRUCE BIOSCIENCES INC. | | 138.95% | -35.0 |  |
 | 165 | Chemomab Therapeutics Ltd. | | 138.90% | -128.0 |  |
 | 166 | Mirati Therapeutics Inc. | | 137.25% | -30.0 |  |
 | 167 | Royalty Pharma plc | | 137.01% | 42.0 |  |
 | 168 | Pulmatrix Inc. | | 136.51% | 13.0 |  |
 | 169 | Liquidia Corp | | 136.34% | 60.0 |  |
 | 170 | Alzamend Neuro Inc. | | 135.23% | 237.0 |  |
 | 171 | Corvus Pharmaceuticals Inc. | | 134.37% | -36.0 |  |
 | 172 | Schrodinger Inc. | | 133.51% | 1.0 |  |
 | 173 | Stoke Therapeutics Inc. | | 132.22% | -59.0 |  |
 | 174 | BeiGene Ltd. | | 131.05% | 14.0 |  |
 | 175 | PFIZER INC | | 130.76% | 76.0 |  |
 | 176 | Arbutus Biopharma Corp | | 129.81% | -5.0 |  |
 | 177 | BICYCLE THERAPEUTICS plc | | 128.96% | 7.0 |  |
 | 178 | Nurix Therapeutics Inc. | | 128.40% | 27.0 |  |
 | 179 | ALPINE IMMUNE SCIENCES INC. | | 127.13% | 102.0 |  |
 | 180 | SUPERNUS PHARMACEUTICALS INC. | | 125.66% | 66.0 |  |
 | 181 | Hepion Pharmaceuticals Inc. | | 123.19% | -68.0 |  |
 | 182 | VYNE Therapeutics Inc. | | 123.03% | 161.0 |  |
 | 183 | ACADIA PHARMACEUTICALS INC | | 121.86% | -3.0 |  |
 | 184 | Pyxis Oncology Inc. | | 119.04% | -104.0 |  |
 | 185 | NightHawk Biosciences Inc. | | 118.81% | -99.0 |  |
 | 186 | Cryoport Inc. | | 118.56% | 71.0 |  |
 | 187 | Elicio Therapeutics Inc. | | 118.35% | 19.0 |  |
 | 188 | BIO-PATH HOLDINGS INC | | 118.32% | -99.0 |  |
 | 189 | Celularity Inc | | 118.13% | 159.0 |  |
 | 190 | LEAP THERAPEUTICS INC. | | 114.49% | -83.0 |  |
 | 191 | Alkermes plc. | | 113.27% | 39.0 |  |
 | 192 | Dianthus Therapeutics Inc. DE | | 112.86% | -71.0 |  |
 | 193 | ARROWHEAD PHARMACEUTICALS INC. | | 112.48% | 54.0 |  |
 | 194 | Eledon Pharmaceuticals Inc. | | 112.09% | -159.0 |  |
 | 195 | Merus N.V. | | 111.90% | 7.0 |  |
 | 196 | RHYTHM PHARMACEUTICALS INC. | | 109.19% | -85.0 |  |
 | 197 | SYNLOGIC INC. | | 109.09% | -43.0 |  |
 | 198 | Xilio Therapeutics Inc. | | 108.28% | -46.0 |  |
 | 199 | IMMUNIC INC. | | 108.27% | -12.0 |  |
 | 200 | Catalent Inc. | | 107.63% | 45.0 |  |
 | 201 | Annovis Bio Inc. | | 106.99% | -137.0 |  |
 | 202 | Landos Biopharma Inc. | | 106.94% | -13.0 |  |
 | 203 | Y-mAbs Therapeutics Inc. | | 106.25% | -73.0 |  |
 | 204 | MARAVAI LIFESCIENCES HOLDINGS INC. | | 104.52% | 81.0 |  |
 | 205 | Genprex Inc. | | 104.48% | -103.0 |  |
 | 206 | Elanco Animal Health Inc | | 104.40% | 61.0 |  |
 | 207 | Biofrontera Inc. | | 103.81% | 178.0 |  |
 | 208 | Lifevantage Corp | | 103.21% | 23.0 |  |
 | 209 | Cue Biopharma Inc. | | 102.52% | 10.0 |  |
 | 210 | Tango Therapeutics Inc. | | 102.48% | -16.0 |  |
 | 211 | Gain Therapeutics Inc. | | 101.52% | -87.0 |  |
 | 212 | Actinium Pharmaceuticals Inc. | | 100.47% | -113.0 |  |
 | 213 | Histogen Inc. | | 99.82% | 29.0 |  |
 | 214 | ORAGENICS INC | | 97.99% | -70.0 |  |
 | 215 | Spero Therapeutics Inc. | | 96.96% | 101.0 |  |
 | 216 | Phio Pharmaceuticals Corp. | | 96.90% | 0.0 |  |
 | 217 | Regulus Therapeutics Inc. | | 96.21% | -21.0 |  |
 | 218 | Viatris Inc | | 95.77% | 71.0 |  |
 | 219 | PERRIGO Co plc | | 94.89% | 31.0 |  |
 | 220 | Decibel Therapeutics Inc. | | 94.13% | -30.0 |  |
 | 221 | ANI PHARMACEUTICALS INC | | 91.74% | 43.0 |  |
 | 222 | MARINUS PHARMACEUTICALS INC. | | 89.18% | 149.0 |  |
 | 223 | Emergent BioSolutions Inc. | | 87.45% | -8.0 |  |
 | 224 | GLYCOMIMETICS INC | | 87.12% | -11.0 |  |
 | 225 | iBio Inc. | | 87.03% | -46.0 |  |
 | 226 | LIXTE BIOTECHNOLOGY HOLDINGS INC. | | 86.37% | 81.0 |  |
 | 227 | Monopar Therapeutics | | 83.65% | -102.0 |  |
 | 228 | ASSEMBLY BIOSCIENCES INC. | | 80.87% | -20.0 |  |
 | 229 | Zoetis Inc. | | 75.92% | 44.0 |  |
 | 230 | CUMBERLAND PHARMACEUTICALS INC | | 75.03% | 19.0 |  |
 | 231 | INTERCEPT PHARMACEUTICALS INC. | | 74.77% | 166.0 |  |
 | 232 | IGM Biosciences Inc. | | 73.72% | 82.0 |  |
 | 233 | BRISTOL MYERS SQUIBB CO | | 73.65% | 55.0 |  |
 | 234 | LEXICON PHARMACEUTICALS INC. | | 73.16% | -14.0 |  |
 | 235 | Eton Pharmaceuticals Inc. | | 72.86% | -28.0 |  |
 | 236 | ARDELYX INC. | | 72.32% | 141.0 |  |
 | 237 | Sio Gene Therapies Inc. | | 71.07% | -153.0 |  |
 | 238 | ARVINAS INC. | | 69.13% | 28.0 |  |
 | 239 | Sonoma Pharmaceuticals Inc. | | 69.03% | 88.0 |  |
 | 240 | BELLICUM PHARMACEUTICALS INC | | 68.90% | -103.0 |  |
 | 241 | Societal CDMO Inc. | | 65.15% | 84.0 |  |
 | 242 | Alaunos Therapeutics Inc. | | 62.60% | 92.0 |  |
 | 243 | PHIBRO ANIMAL HEALTH CORP | | 62.17% | 53.0 |  |
 | 244 | Unity Biotechnology Inc. | | 60.43% | 79.0 |  |
 | 245 | Virpax Pharmaceuticals Inc. | | 60.31% | -168.0 |  |
 | 246 | TFF Pharmaceuticals Inc. | | 59.80% | -54.0 |  |
 | 247 | MACROGENICS INC | | 59.45% | 18.0 |  |
 | 248 | VERU INC. | | 57.75% | -192.0 |  |
 | 249 | ELI LILLY & Co | | 56.75% | 66.0 |  |
 | 250 | 2seventy bio Inc. | | 55.59% | 56.0 |  |
 | 251 | Ampio Pharmaceuticals Inc. | | 51.21% | -15.0 |  |
 | 252 | Guardion Health Sciences Inc. | | 51.16% | -4.0 |  |
 | 253 | Imunon Inc. | | 49.67% | 0.0 |  |
 | 254 | NEKTAR THERAPEUTICS | | 49.51% | 22.0 |  |
 | 255 | GYRE THERAPEUTICS INC. | | 48.38% | 132.0 |  |
 | 256 | Vincerx Pharma Inc. | | 46.88% | -110.0 |  |
 | 257 | KIORA PHARMACEUTICALS INC | | 46.16% | 111.0 |  |
 | 258 | Korro Bio Inc. | | 43.13% | -19.0 |  |
 | 259 | Vaxxinity Inc. | | 42.12% | 18.0 |  |
 | 260 | Mirum Pharmaceuticals Inc. | | 38.51% | 53.0 |  |
 | 261 | AILERON THERAPEUTICS INC | | 36.90% | -100.0 |  |
 | 262 | LIFECORE BIOMEDICAL INC. \DE\ | | 36.74% | 20.0 |  |
 | 263 | Petros Pharmaceuticals Inc. | | 36.11% | -9.0 |  |
 | 264 | Sigilon Therapeutics Inc. | | 34.79% | 48.0 |  |
 | 265 | RVL Pharmaceuticals plc | | 34.32% | 32.0 |  |
 | 266 | NovaBay Pharmaceuticals Inc. | | 33.59% | 36.0 |  |
 | 267 | Atreca Inc. | | 32.55% | -43.0 |  |
 | 268 | TEVA PHARMACEUTICAL INDUSTRIES LTD | | 31.50% | 50.0 |  |
 | 269 | IONIS PHARMACEUTICALS INC | | 31.29% | 36.0 |  |
 | 270 | Blueprint Medicines Corp | | 29.71% | -49.0 |  |
 | 271 | NeuBase Therapeutics Inc. | | 28.98% | -104.0 |  |
 | 272 | Corbus Pharmaceuticals Holdings Inc. | | 28.83% | -9.0 |  |
 | 273 | COLLEGIUM PHARMACEUTICAL INC | | 28.80% | 21.0 |  |
 | 274 | PUMA BIOTECHNOLOGY INC. | | 28.61% | 0.0 |  |
 | 275 | Tharimmune Inc. | | 27.11% | 171.0 |  |
 | 276 | MEI Pharma Inc. | | 23.54% | 81.0 |  |
 | 277 | Summit Therapeutics Inc. | | 23.17% | 7.0 |  |
 | 278 | HARROW INC. | | 22.79% | 87.0 |  |
 | 279 | DURECT CORP | | 20.30% | -145.0 |  |
 | 280 | CHINA PHARMA HOLDINGS INC. | | 18.61% | 51.0 |  |
 | 281 | PIERIS PHARMACEUTICALS INC. | | 17.44% | 52.0 |  |
 | 282 | RenovoRx Inc. | | 17.21% | -182.0 |  |
 | 283 | ImmunoGen Inc. | | 16.64% | -43.0 |  |
 | 284 | Marker Therapeutics Inc. | | 15.36% | 0.0 |  |
 | 285 | ROCKWELL MEDICAL INC. | | 14.25% | 108.0 |  |
 | 286 | Arcutis Biotherapeutics Inc. | | 14.11% | -48.0 |  |
 | 287 | CHEMBIO DIAGNOSTICS INC. | | 13.87% | 35.0 |  |
 | 288 | Verastem Inc. | | 10.77% | -55.0 |  |
 | 289 | ABEONA THERAPEUTICS INC. | | 8.64% | 71.0 |  |
 | 290 | Acurx Pharmaceuticals Inc. | | 8.55% | -56.0 |  |
 | 291 | Virios Therapeutics Inc. | | 7.52% | -38.0 |  |
 | 292 | EYENOVIA INC. | | 7.28% | -37.0 |  |
 | 293 | VBI Vaccines Inc BC | | 6.96% | -67.0 |  |
 | 294 | Earth Science Tech Inc. | | 6.94% | 166.0 |  |
 | 295 | Iterum Therapeutics plc | | 6.72% | 77.0 |  |
 | 296 | Aeglea BioTherapeutics Inc. | | 5.86% | -55.0 |  |
 | 297 | Amneal Pharmaceuticals Inc. | | 4.99% | 54.0 |  |
 | 298 | MUSTANG BIO INC. | | 2.98% | -135.0 |  |
 | 299 | Aptinyx Inc. | | 2.11% | -77.0 |  |
 | 300 | Axsome Therapeutics Inc. | | 0.47% | 0.0 |  |
 | 301 | Bausch Health Companies Inc. | | 0.37% | 66.0 |  |
 | 302 | Sarepta Therapeutics Inc. | | -1.44% | 22.0 |  |
 | 303 | GERON CORP | | -2.87% | -2.0 |  |
 | 304 | AMICUS THERAPEUTICS INC. | | -5.05% | 26.0 |  |
 | 305 | Xeris Biopharma Holdings Inc. | | -5.26% | 48.0 |  |
 | 306 | GT Biopharma Inc. | | -6.45% | 0.0 |  |
 | 307 | OCULAR THERAPEUTIX INC | | -7.74% | -38.0 |  |
 | 308 | Equillium Inc. | | -11.82% | -96.0 |  |
 | 309 | Evoke Pharma Inc | | -12.22% | 71.0 |  |
 | 310 | International Stem Cell CORP | | -13.53% | 69.0 |  |
 | 311 | Cellectar Biosciences Inc. | | -13.94% | -112.0 |  |
 | 312 | Mersana Therapeutics Inc. | | -15.94% | 28.0 |  |
 | 313 | G1 Therapeutics Inc. | | -19.09% | -2.0 |  |
 | 314 | BioXcel Therapeutics Inc. | | -20.13% | -191.0 |  |
 | 315 | Edesa Biotech Inc. | | -20.35% | 0.0 |  |
 | 316 | Akebia Therapeutics Inc. | | -22.03% | 66.0 |  |
 | 317 | Eterna Therapeutics Inc. | | -23.14% | 131.0 |  |
 | 318 | Goodness Growth Holdings Inc. | | -23.21% | 20.0 |  |
 | 319 | Kintara Therapeutics Inc. | | -23.62% | 0.0 |  |
 | 320 | REVIVA PHARMACEUTICALS HOLDINGS INC. | | -24.72% | 0.0 |  |
 | 321 | Calithera Biosciences Inc. | | -24.76% | 82.0 |  |
 | 322 | Evolus Inc. | | -25.34% | 4.0 |  |
 | 323 | NexImmune Inc. | | -25.83% | -165.0 |  |
 | 324 | AYTU BIOPHARMA INC | | -26.96% | -56.0 |  |
 | 325 | Foghorn Therapeutics Inc. | | -27.34% | 31.0 |  |
 | 326 | MARIZYME INC. | | -27.35% | -135.0 |  |
 | 327 | Applied Molecular Transport Inc. | | -28.15% | -109.0 |  |
 | 328 | SPECTRUM PHARMACEUTICALS INC | | -30.62% | 82.0 |  |
 | 329 | Dare Bioscience Inc. | | -31.18% | -43.0 |  |
 | 330 | Travere Therapeutics Inc. | | -31.63% | -20.0 |  |
 | 331 | Qualigen Therapeutics Inc. | | -32.20% | -40.0 |  |
 | 332 | ALIMERA SCIENCES INC | | -33.34% | -201.0 |  |
 | 333 | CymaBay Therapeutics Inc. | | -35.53% | -73.0 |  |
 | 334 | InMed Pharmaceuticals Inc. | | -36.19% | -13.0 |  |
 | 335 | ALNYLAM PHARMACEUTICALS INC. | | -38.86% | 26.0 |  |
 | 336 | BODY & MIND INC. | | -41.58% | 0.0 |  |
 | 337 | Fortress Biotech Inc. | | -47.48% | -54.0 |  |
 | 338 | FIBROGEN INC | | -48.62% | 17.0 |  |
 | 339 | vTv Therapeutics Inc. | | -49.57% | -22.0 |  |
 | 340 | Immunome Inc. | | -52.50% | -155.0 |  |
 | 341 | Karyopharm Therapeutics Inc. | | -53.03% | 60.0 |  |
 | 342 | CYTOKINETICS INC | | -53.89% | -5.0 |  |
 | 343 | RIGEL PHARMACEUTICALS INC | | -58.13% | -127.0 |  |
 | 344 | Revance Therapeutics Inc. | | -58.19% | 40.0 |  |
 | 345 | eFFECTOR Therapeutics Inc. | | -58.88% | -83.0 |  |
 | 346 | Hoth Therapeutics Inc. | | -60.99% | -27.0 |  |
 | 347 | HERON THERAPEUTICS INC. DE | | -64.99% | 36.0 |  |
 | 348 | SCYNEXIS INC | | -66.42% | -20.0 |  |
 | 349 | Athenex Inc. | | -67.01% | 41.0 |  |
 | 350 | Seres Therapeutics Inc. | | -67.44% | -42.0 |  |
 | 351 | GELESIS HOLDINGS INC. | | -70.54% | -241.0 |  |
 | 352 | CV Sciences Inc. | | -72.77% | 39.0 |  |
 | 353 | MADRIGAL PHARMACEUTICALS INC. | | -76.27% | 41.0 |  |
 | 354 | CytomX Therapeutics Inc. | | -81.21% | 15.0 |  |
 | 355 | Innovation1 Biotech Inc. | | -85.28% | 79.0 |  |
 | 356 | CTI BIOPHARMA CORP | | -91.48% | 64.0 |  |
 | 357 | OptiNose Inc. | | -99.82% | 41.0 |  |
 | 358 | GRI BIO Inc. | | -100.46% | 0.0 |  |
 | 359 | Aravive Inc. | | -102.06% | -67.0 |  |
 | 360 | Minerva Neurosciences Inc. | | -102.23% | 29.0 |  |
 | 361 | Jaguar Health Inc. | | -106.10% | 43.0 |  |
 | 362 | Praxis Precision Medicines Inc. | | -107.85% | -162.0 |  |
 | 363 | Emmaus Life Sciences Inc. | | -107.93% | 43.0 |  |
 | 364 | BIOVIE INC. | | -108.16% | 102.0 |  |
 | 365 | LANNETT CO INC | | -108.76% | 27.0 |  |
 | 366 | Molecular Templates Inc. | | -112.98% | -16.0 |  |
 | 367 | SOLIGENIX INC. | | -116.38% | -28.0 |  |
 | 368 | AVADEL PHARMACEUTICALS PLC | | -122.10% | -27.0 |  |
 | 369 | MANNKIND CORP | | -123.25% | 44.0 |  |
 | 370 | 9 METERS BIOPHARMA INC. | | -124.07% | -133.0 |  |
 | 371 | ONCOSEC MEDICAL Inc | | -124.84% | -62.0 |  |
 | 372 | ABVC BIOPHARMA INC. | | -131.27% | -36.0 |  |
 | 373 | One World Products Inc. | | -131.62% | 29.0 |  |
 | 374 | Timber Pharmaceuticals Inc. | | -135.48% | -122.0 |  |
 | 375 | Wave Life Sciences Ltd. | | -136.94% | 6.0 |  |
 | 376 | Paratek Pharmaceuticals Inc. | | -138.63% | 38.0 |  |
 | 377 | Salarius Pharmaceuticals Inc. | | -145.33% | -298.0 |  |
 | 378 | UroGen Pharma Ltd. | | -146.16% | 30.0 |  |
 | 379 | INFINITY PHARMACEUTICALS INC. | | -149.27% | -5.0 |  |
 | 380 | Avalo Therapeutics Inc. | | -155.65% | 16.0 |  |
 | 381 | IntelGenx Technologies Corp. | | -156.03% | -3.0 |  |
 | 382 | Phathom Pharmaceuticals Inc. | | -161.41% | -7.0 |  |
 | 383 | IMPEL PHARMACEUTICALS INC | | -164.75% | -34.0 |  |
 | 384 | AXIM BIOTECHNOLOGIES INC. | | -171.51% | 0.0 |  |
 | 385 | Q BioMed Inc. | | -171.60% | 76.0 |  |
 | 386 | SELLAS Life Sciences Group Inc. | | -177.98% | -115.0 |  |
 | 387 | REVELATION BIOSCIENCES INC. | | -181.21% | -290.0 |  |
 | 388 | Evelo Biosciences Inc. | | -183.92% | 31.0 |  |
 | 389 | Esperion Therapeutics Inc. | | -192.90% | 29.0 |  |
 | 390 | Transcode Therapeutics Inc. | | -200.93% | -275.0 |  |
 | 391 | Cyclerion Therapeutics Inc. | | -203.07% | -121.0 |  |
 | 392 | BIORA THERAPEUTICS INC. | | -204.54% | 49.0 |  |
 | 393 | AGILE THERAPEUTICS INC | | -205.41% | 35.0 |  |
 | 394 | Applied Therapeutics Inc. | | -207.65% | -32.0 |  |
 | 395 | BridgeBio Pharma Inc. | | -210.70% | 28.0 |  |
 | 396 | Aquestive Therapeutics Inc. | | -222.03% | 36.0 |  |
 | 397 | AMERICAN BIO MEDICA CORP | | -226.50% | 14.0 |  |
 | 398 | First Wave BioPharma Inc. | | -228.61% | 58.0 |  |
 | 399 | Skye Bioscience Inc. | | -232.27% | -53.0 |  |
 | 400 | Greater Cannabis Company Inc. | | -234.67% | 35.0 |  |
 | 401 | DMK PHARMACEUTICALS Corp | | -245.18% | -31.0 |  |
 | 402 | Regen BioPharma Inc | | -248.60% | 45.0 |  |
 | 403 | GALECTIN THERAPEUTICS INC | | -251.86% | -8.0 |  |
 | 404 | Retrieve Medical Holdings Inc. | | -268.60% | 0.0 |  |
 | 405 | CANNAPHARMARX INC. | | -270.17% | 53.0 |  |
 | 406 | ATHERSYS INC NEW | | -274.91% | -1.0 |  |
 | 407 | Acer Therapeutics Inc. | | -275.27% | -19.0 |  |
 | 408 | PROVECTUS BIOPHARMACEUTICALS INC. | | -276.97% | 29.0 |  |
 | 409 | Benitec Biopharma Inc. | | -290.07% | -243.0 |  |
 | 410 | SANGUI BIOTECH INTERNATIONAL INC | | -290.31% | 32.0 |  |
 | 411 | Evofem Biosciences Inc. | | -291.46% | 41.0 |  |
 | 412 | TENAX THERAPEUTICS INC. | | -319.01% | 0.0 |  |
 | 413 | CONTRAFECT Corp | | -321.42% | 0.0 |  |
 | 414 | SEELOS THERAPEUTICS INC. | | -327.20% | -110.0 |  |
 | 415 | SYBLEU Inc | | -335.36% | -407.0 |  |
 | 416 | AgeX Therapeutics Inc. | | -338.73% | 0.0 |  |
 | 417 | NORTHWEST BIOTHERAPEUTICS INC | | -339.09% | 0.0 |  |
 | 418 | Kaya Holdings Inc. | | -352.62% | 8.0 |  |
 | 419 | Biostax Corp. | | -353.95% | 12.0 |  |
 | 420 | Avenir Wellness Solutions Inc. | | -362.56% | -100.0 |  |
 | 421 | REGENERX BIOPHARMACEUTICALS INC | | -363.61% | 15.0 |  |
 | 422 | KINETA INC. DE | | -366.95% | -58.0 |  |
 | 423 | Nascent Biotech Inc. | | -368.43% | 6.0 |  |
 | 424 | REGENEREX PHARMA INC. | | -371.04% | 29.0 |  |
 | 425 | RespireRx Pharmaceuticals Inc. | | -377.95% | 25.0 |  |
 | 426 | Rebus Holdings Inc. | | -382.22% | 4.0 |  |
 | 427 | VACCINEX INC. | | -386.41% | -2.0 |  |
 | 428 | Ensysce Biosciences Inc. | | -394.17% | 5.0 |  |
 | 429 | Aprea Therapeutics Inc. | | -398.31% | -219.0 |  |
 | 430 | Cell Source Inc. | | -399.86% | 24.0 |  |
 | 431 | HST Global Inc. | | -408.73% | 24.0 |  |
 | 432 | BIOXYTRAN INC | | -412.48% | 31.0 |  |
 | 433 | Checkpoint Therapeutics Inc. | | -417.41% | -57.0 |  |
 | 434 | CNBX Pharmaceuticals Inc. | | -421.88% | -80.0 |  |
 | 435 | ENDONOVO THERAPEUTICS INC. | | -424.98% | 8.0 |  |
 | 436 | HUMANIGEN INC | | -437.18% | 9.0 |  |
 | 437 | BIOADAPTIVES INC. | | -444.54% | 0.0 |  |
 | 438 | NEXIEN BIOPHARMA INC. | | -452.02% | 0.0 |  |
 | 439 | ProtoKinetix Inc. | | -468.92% | 25.0 |  |
 | 440 | Vicapsys Life Sciences Inc. | | -478.64% | -41.0 |  |
 | 441 | Sonnet BioTherapeutics Holdings Inc. | | -480.16% | -151.0 |  |
 | 442 | CytoDyn Inc. | | -488.56% | -21.0 |  |
 | 443 | America Great Health | | -508.99% | -26.0 |  |
 | 444 | Propanc Biopharma Inc. | | -510.47% | 15.0 |  |
 | 445 | Bioquest Corp | | -626.22% | 17.0 |  |
 | 446 | Scopus BioPharma Inc. | | -836.06% | -2.0 |  |